The role of MuLV receptors on T-lymphoma cells in lymphoma cell proliferation.
The role of MuLV receptors on T-lymphoma cells in lymphoma cell proliferation.
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MuLV 受体在 T 淋巴瘤细胞增殖中的作用。
DOI：
10.1007/978-1-4684-3701-0_5
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
I. Weissman
中科院分区：
文献类型：
--
作者：
M. McGrath;E. Pillemer;D. Kooistra;I. Weissman
小鼠白血病病毒（MuLV）诱导小鼠胸腺淋巴细胞肿瘤涉及内源性逆转录病毒基因序列与胸腺靶细胞之间的一系列复杂相互作用（Kaplan，1967）。与感染相比，这种病毒-细胞相互作用的特征在于对转化的精确靶细胞特异性。因此，一些高度纯化的逆转录病毒（例如，Moloney），其可以感染小鼠成纤维细胞和胸腺（或T）细胞，但是其仅能够转化有限的胸腺细胞亚群（N. Rosenberg，personal communication; Buchelor et al.，1976年）。由于白血病细胞的分离株感染成纤维细胞而不转化，而成纤维细胞的分离株既能感染又能转化某些T淋巴细胞，显然转化病毒与其靶细胞之间一定存在某种非常特殊的关系（Weissman和Baird综述，1977）。
The induction of thymic lymphocytic neoplasms in mice by murine leukemia viruses (MuLV) involves a complex series of interactions between endogenous retroviral gene sequences and target cells in the thymus (Kaplan, 1967). This virus-cell interaction is characterized by an exquisite target cell specificity for transformation, as compared to infection. Thus, some highly purified retroviruses (e.g., Moloney) can be obtained which can infect both mouse fibroblasts and thymic (or T) cells, but which are capable of transforming only a limited subset of thymocytes (N. Rosenberg, personal communication; Buchhagen et al., 1976). Since isolates from leukemic cells infect fibroblasts without transformation, and isolates from fibroblasts can both infect and transform some T lymphocytes, it is apparent that some very special relationship must exist between the transforming virus and its target cell (reviewed by Weissman and Baird, 1977).