Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women
Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women
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DOI：
10.3177/jnsv.50.114
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发表时间：
2004-04-01
影响因子：
1.6
通讯作者：
Sunami, S
中科院分区：
文献类型：
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作者：
Katsuyama, H;Ideguchi, S;Sunami, S
一种维生素K-2治疗剂在日本被批准用于治疗骨质疏松症。然而，人们对膳食摄入维生素K-2对骨骼健康的功效知之甚少。我们比较了不同水平的发酵大豆（纳豆）摄入量的影响。它含有大量的维生素K-2，对健康绝经前妇女的骨硬度和骨转换标志物有影响。73名健康的绝经前妇女根据年龄和胎次被随机分为四组。纳豆饲喂方式为：组1（不饲喂）、组2（每月1次）、组3（每周1次）、组4（每周3次）。受试者在一顿午餐中食用纳豆。y，分别在基线、6个月和1个月评估定量超声和骨转换标志物的刚度指数。1个月观察期间的刚度指数无统计学差异。但在1 d时，4组骨特异性碱性磷酸酶（BAP）高于3组，6 d时，4组低羧化骨钙素（Glu）显著低于1、2和3组。Logistic回归分析显示，在1组的基础上，4组骨形成标志物降低的风险降低至0.07。在绝经前必须保持尽可能高的僵硬指数的绝经前妇女中，纳豆的摄入可能有助于促进骨骼形成。
A therapeutic agent of vitamin K-2 is approved for the treatment of osteoporosis in Japan. However, little is known about the efficacy of dietary intake of vitamin K-2 for bone health. We compared the effects of various levels of fermented soybeans (Natto) intake. which contains plenty of vitamin K-2, on bone stiffness and bone turnover markers in healthy premenopausal women. Seventy-three healthy premenopausal women were randomly divided into four groups matched for age and parity categories. Natto was supplied as follows: Group 1 (no intake), Group 2 (once per month), Group 3 (once per week) and Group 4 (three times per week). Subjects took Natto at a lunch for 1. y, and the stiffness index by quantitative ultrasound and bone turnover markers were assessed at baseline, 6 mo and 1 y. There was no statistical difference in the stiffness index during the 1 y observation. However, bone specific alkaline phosphatase (BAP) in Group 4 was higher than that in Group 3 at 1 y and undercarboxylated osteocalcin (Glu) in Group 4 was significantly lower than those in Groups 1, 2 and 3 at 6 me. Logistic regression analysis showed that the risk of reduction of bone formation markers declined to 0.07 in Group 4 based on that in Group 1. In premenopausal women who had to keep the stiffness index as high as possible before menopause, Natto intake may have contributed to the promotion of bone formation.