Whole-body total lesion glycolysis is an independent predictor in patients with esophageal cancer treated with definitive chemoradiotherapy
Whole-body total lesion glycolysis is an independent predictor in patients with esophageal cancer treated with definitive chemoradiotherapy
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DOI：
10.1016/j.radonc.2017.10.019
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发表时间：
2018-10-01
影响因子：
5.7
通讯作者：
Jingu, Keiichi
中科院分区：
文献类型：
--
作者：
Takahashi, Noriyoshi;Umezawa, Rei;Jingu, Keiichi
背景与目的：探讨全身病变糖酵解(TLGWB)和代谢性肿瘤体积(MTVWB)与确定性放化疗(DCRT)治疗食道癌患者预后的关系。材料和方法：回顾分析2005-2013年间90例胸段食道癌患者在接受放射治疗前45天内接受FDG-PET/CT检查的临床资料。计算原发灶(MTVpri和TLGpri)的MTV和TLG，以及所有病灶(MTVWB和TLGWB)的MTV和TLG之和。预测因素采用COX比例风险模型进行分析。结果：中位随访期为27.7个月。在多变量分析中，MTVWB和GT；中位数是OS(p=0.027，风险比：2.15)、LC(p=0.039，HR：1.98)和PFS(p=0.041，HR：1.96)的不利预测因素。TLGWB和GT；中位数是OS(p=0.019，HR：2.26)、LC(p=0.015，HR：2.36)和PFS(p=0.014，HR：2.33)的不良预测因子。多因素分析显示，对于OS、LC和PFS，TLGWB的HR高于MTVWB，SUVmax不是预测因素。结论：TLGWB和MTVWB是食道癌患者的独立预测因子。(C)2017爱思唯尔B.V.保留所有权利。放射治疗与肿瘤学
Background and purpose: To determine whether pretreatment whole-body total lesion glycolysis (TLGWB) and metabolic tumor volume (MTVWB) are associated with outcomes in patients with esophageal cancer treated with definitive chemoradiotherapy (dCRT). Materials and methods: Ninety patients with stage II or III thoracic esophageal cancer who underwent FDG-PET/ CT within 45 days before dCRT between 2005 and 2013 were reviewed. MTV and TLG of the primary lesion (MTVpri and TLGpri) and the sum of MTV and TLG for all lesions (MTVWB and TLGWB) were calculated. Predictors were analyzed using the Cox proportional hazards model. Results: The median follow-up period was 27.7 months. In multivariate analysis, MTVWB > median was an unfavorable predictor for OS (p = 0.027, hazard ratio [ HR]: 2.15), LC (p = 0.039, HR: 1.98) and PFS (p = 0.041, HR: 1.96). TLGWB > median was an unfavorable predictor for OS (p = 0.019, HR: 2.26), LC (p = 0.015, HR: 2.36) and PFS (p = 0.014, HR: 2.33). SUVmax was not a predictor, and the HR of TLGWB was higher than that of MTVWB for OS, LC and PFS in multivariate analysis. Conclusion: TLGWB and MTVWB are independent predictors in patients with esophageal cancer. (C) 2017 Elsevier B. V. All rights reserved. Radiotherapy and Oncology