Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)
Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)
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DOI：
10.1016/j.atherosclerosis.2014.12.033
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发表时间：
2015-03-01
期刊：
影响因子：
5.3
通讯作者：
Allison, Matthew A.
中科院分区：
文献类型：
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作者：
Martin, Seth S.;Blaha, Michael J.;Allison, Matthew A.
目的：在主要涉及白种人男性的研究中，较高的血清瘦素水平与心血管疾病的适度高发病率相关。我们的目的是在不同的队列中评估高基线水平的血清瘦素与未来心血管疾病高风险相关的假设。方法：动脉粥样硬化多种族研究（MESA）是一项现代、基于社区、种族多样化、性别平衡的前瞻性队列研究，研究对象为无心血管疾病的美国成年人。在2002-2005年的一项辅助研究中测定了血清瘦素。该分析包括1905名MESA参与者，他们有基线瘦素和心血管事件数据。瘦素水平被建模为一个对数转换的连续变量，并对包括冠心病和中风在内的硬心血管疾病的主要结局进行多变量调整的Cox回归。结果：中位随访时间为7.6年（25 -75期7.1-8.3），女性和男性分别为7051和6738人年。47名女性和63名男性发生了严重的心血管疾病。年龄和种族校正后ln（瘦素）增加1个标准差的风险比估计在女性中为1.16 (95% CI 0.78-1.73, p = 0.46)，在男性中为0.91 （95% CI 0.69-1.20, p = 0.51）。合并性别，并调整性别、年龄和种族，估计为0.98 （95% CI 0.78-1.23, p = 0.89）。对心血管危险因素进行额外调整后，结果仍然不显著：0.87 （95% CI 0.68-1.11, p = 0.26）。结论：总而言之，在美国一项针对多种族背景的多种族女性和男性的现代前瞻性队列研究中，瘦素水平与心血管事件的发生无关。2014爱思唯尔爱尔兰有限公司版权所有。
Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort.Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a logtransformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke.Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age-and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p = 0.46) and 0.91 (95% CI 0.69-1.20, p = 0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p = 0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p = 0.26).Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events. (C) 2014 Elsevier Ireland Ltd. All rights reserved.