Inflammatory and immune pathways in the pathogenesis of periodontal disease.
Inflammatory and immune pathways in the pathogenesis of periodontal disease.
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DOI：
10.1111/prd.12002
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发表时间：
2014-02
影响因子：
18.6
通讯作者：
Van Dyke TE
中科院分区：
文献类型：
--
作者：
Cekici A;Kantarci A;Hasturk H;Van Dyke TE
牙周炎的发病机制涉及由牙齿上自然形成的口腔生物膜的细菌引发的复杂的免疫/炎症级联反应。牙周炎的易感性似乎是由宿主反应决定的，具体来说，炎症反应的程度和免疫途径的差异激活。这篇综述的目的是描述我们目前对牙周炎宿主反应的认识。先天免疫的作用，急性炎症的失败，以解决（从而成为慢性），调节获得性免疫和免疫系统的细胞和产品的激活的细胞因子途径被认为是。有关炎症和免疫反应的调节的新信息将在易感性的背景下进行审查，也许控制，牙周炎。
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility to periodontitis appears to be determined by the host response; specifically, the magnitude of the inflammatory response and the differential activation of immune pathways. The purpose of this review was to delineate our current knowledge of the host response in periodontitis. The role of innate immunity, the failure of acute inflammation to resolve (thus becoming chronic), the cytokine pathways that regulate the activation of acquired immunity and the cells and products of the immune system are considered. New information relating to regulation of both inflammation and the immune response will be reviewed in the context of susceptibility to, and perhaps control of, periodontitis.