Deposition of inhaled electronic cigarette aerosol in the human oral cavity
Deposition of inhaled electronic cigarette aerosol in the human oral cavity
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DOI：
10.1016/j.jaerosci.2017.11.014
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发表时间：
2018-02-01
影响因子：
4.5
通讯作者：
Pithawalla, Yezdi B.
中科院分区：
文献类型：
--
作者：
Asgharian, Bahman;Price, Owen T.;Pithawalla, Yezdi B.
电子烟（EC）产品使用的增加要求研究这些新产品对健康的影响。FDA等政府机构对毒理学、暴露数据和其他相关信息感兴趣，作为监管产品使用的一部分。EC产品风险评估的关键步骤是确定EC气雾剂中各种成分的吸入剂量。鉴于收集人类和动物数据的挑战，数学模型可以指导和补充数据收集。为可燃烟草烟雾开发的模型可以改进并扩展到EC气溶胶，以允许后者具有更高的挥发性和吸湿性。这两种性质极大地影响了吸入气溶胶的动力学和沉积。在这项研究中，我们开发了一个沉积模型的EC气溶胶的基础上现实的vaping方案。该模型包括几个步骤，代表抽吸撤回到口腔中、口部保持、EC抽吸在口中的稀释以及随后从吸入空气的稀释、抽吸吸入到下呼吸道中、肺保持和呼气。本出版物将介绍呼吸道口腔内单个成分的沉积和液滴动力学的结果。该模型考虑了气溶胶混合物中每种成分的液滴和汽相之间的热力学相互作用。计算了液滴的沉积和蒸气组分的吸收。还基于吸入成分的总质量计算每种蒸气成分和液滴的沉积质量分数。本研究所建立之吸入模型，可协助学术界、政府机关及烟草制造业发展乳油使用之风险模型。
Increased use of electronic cigarette (EC) products has called for studying the health consequences from these new products. Government agencies such as the FDA are interested in toxicological, exposure data and other relevant information as a part of regulating the use of the products. A key step in risk assessment of EC products is to determine the inhaled dose of various constituents in the EC aerosol. Given the challenges in collecting human and animal data, mathematical models may guide and complement data collection. Models developed for combustible tobacco smoke may be improved and extended to EC aerosol to allow for higher volatility and hygroscopicity of the latter. Both these properties greatly affect the dynamics and deposition of inhaled aerosol. In this study, we developed a deposition model for EC aerosol based on realistic vaping scenarios. The model included several steps representing puff withdrawal into the oral cavity, mouth hold, dilution of the EC puff in the mouth with the subsequent dilution from inhaled air, inhalation of the puff into the lower respiratory tract, lung-hold, and exhalation. Results for deposition of individual constituents and droplet dynamics within the oral cavity of the respiratory tract will be presented in this publication. The model accounted for thermodynamic interactions between the droplet and vapor phases of each constituent in the aerosol mixture. Deposition from droplets and uptake of vapor constituents were calculated. The deposited mass fraction for each vapor constituent and droplets were also calculated based on the total mass of the inhaled constituents. The inhalation model developed in this study could help the academics, government agencies and tobacco manufacturers with development of risk models for EC use.