Age-associated changes of mitochondrial translation and respiratory function in mouse brain.
Age-associated changes of mitochondrial translation and respiratory function in mouse brain.
复制标题
小鼠大脑中线粒体翻译和呼吸功能与年龄相关的变化。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
J. Hayashi
中科院分区：
文献类型：
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作者：
D. Takai;K. Inoue;H. Shisa;Y. Kagawa;J. Hayashi
我们研究了与年龄相关的变化，呼吸酶活性和蛋白质合成的线粒体分离自小鼠脑高氧化活性。细胞色素c氧化酶活性意外地增加与老化，而线粒体翻译活动显示两个阶段的改变：他们逐渐增加到出生后21周，然后随着年龄的增长逐渐下降。结果表明，这些变化不是由于线粒体DNA（mtDNA）拷贝数的变化或缺失突变的积累。这些观察结果表明，人类和小鼠线粒体功能的年龄相关变化的共同特征仅限于线粒体翻译活性的降低。因此，小鼠脑可以作为一个模型，以了解衰老和线粒体功能之间的关系，通过检查线粒体翻译活性下降的原因。
We examined age-associated changes of respiratory enzyme activities and protein synthesis in mitochondria isolated from mouse brain with high oxidative activities. Cytochrome c oxidase activity increased unexpectedly with aging, while the mitochondrial translational activities showed two phases of alterations: they increased progressively up to 21 weeks after birth followed by a gradual decrease with aging. Results showed that these changes were not due to the change in mitochondrial DNA (mtDNA) copy number or the accumulation of deletion mutations in mtDNA. These observations suggest that the common feature of age-associated changes in both human and mouse mitochondrial functions is limited to the decrease in mitochondrial translational activity. Therefore, mouse brain can be used as a model to understand the relationships between aging and mitochondrial function by examining the cause of decrease in mitochondrial translation activity.