EFFECT OF CHRONIC CALORIC RESTRICTION ON PHYSIOLOGICAL VARIABLES RELATED TO ENERGY-METABOLISM IN THE MALE FISCHER-344 RAT
EFFECT OF CHRONIC CALORIC RESTRICTION ON PHYSIOLOGICAL VARIABLES RELATED TO ENERGY-METABOLISM IN THE MALE FISCHER-344 RAT
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DOI：
10.1016/0047-6374(89)90044-4
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发表时间：
1989-05-01
影响因子：
5.3
通讯作者：
HART, RW
中科院分区：
文献类型：
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作者：
DUFFY, PH;FEUERS, RJ;HART, RW
在本研究中，在19个月大的雄性Fishcer 344大鼠中连续监测了与代谢相关的一些生理行为指标，这些大鼠自由采食或喂食有色限制饮食。热量限制的大鼠进食较少，但在每餐消耗更多的食物，每餐花费更多的时间吃比随意喂养的大鼠。因此，吃饭的时间和持续时间以及消耗的卡路里总数可能与寿命延长有关。每天的平均体温显着降低限制大鼠，但每天的体温范围和运动活动的限制大鼠较高。当碳水化合物储备耗尽时，热量限制大鼠的呼吸商发生显著变化，表明代谢途径的快速变化和较低的温度。在这段时间内，较低的体温和新陈代谢可能会导致较少的DNA损伤，从而增加限制大鼠的生存潜力。夜间喂养被认为是同步的生理表现之间的自由和热量限制大鼠比白天喂养，从而使研究人员区分热量限制的影响，从那些只与时间的一天的喂养。
In the present study, a number of physiological behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fishcer 344 rats that were fed ad libitum or fed a coloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent more time eating per meal than did rats fed ad libitum. Therefore, the timing and duration of meals as well as the total number of calories consumed may be associated with life extension. Average body temperature per day was significantly lower in restricted rats but body temperature range per day and motor activity were higher in restricted rats. Dramatic changes in respiratory quotient, indicating rapid changes in metabolic pathway and lower temperature, occurred in caloric restricted rats when carbohydrate reserves were depleted. Lower body temperature and metabolism during this time interval may result in less DNA damage, thereby increasing the survival potential of restricted rats. Nighttime feeding was found to synchronize physiological performance between ad libitum and caloric restricted rats better than daytime feeding, thereby allowing investigators to distinguish the effects of caloric restriction from those related solely to the time-of-day of feeding.