Local Introduction of Drugs into the Arterial Wall: A Percutaneous Catheter Technique
Local Introduction of Drugs into the Arterial Wall: A Percutaneous Catheter Technique
复制标题
将药物局部引入动脉壁：经皮导管技术
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
S. Thung
中科院分区：
文献类型：
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作者：
H. Wolinsky;S. Thung
A method is described by which agents can be introduced directly into the arterial wall via the percutaneous approach. A perforated balloon catheter has been developed to accomplish this. Several major theoretical hurdles have been overcome. Specifically, heparin in high doses can be introduced in arterial segments and shown to be retained for at least 48 hours. The use of high dose heparin to inhibit cell proliferation underlying restenosis after angioplasty is discussed. Other potential drug applications for restenosis, atherosclerosis, and study of metabolic activity of arterial tissue are discussed. The advantages of this method over prolonged intravenous drug delivery are obvious. Further studies of clinical applicability seem worthwhile. (J Interven Cardiol 1989:2:4)
一种放射性碘标记的细胞内捕获配体，用于确定体内血浆蛋白降解的位点。
DOI：
10.1042/bj2120791
发表时间：
1983
期刊：
The Biochemical journal
影响因子：
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作者：
Pittman,RC;Carew,TE;Glass,CK;Green,SR;TaylorJr,CA;Attie,AD
通讯作者：
Attie,AD
动脉损伤后细胞增殖的动力学。
DOI：
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发表时间：
1985
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Clowes,AW;Clowes,MM
通讯作者：
Clowes,MM