An energy-optimal approach for entrainment of uncertain circadian oscillators.
An energy-optimal approach for entrainment of uncertain circadian oscillators.
复制标题
用于夹带不确定昼夜节律振荡器的能量最佳方法。
DOI：
10.1016/j.bpj.2014.08.013
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发表时间：
2014
影响因子：
3.4
通讯作者：
J. Moehlis
中科院分区：
文献类型：
--
作者：
Dan Wilson;J. Moehlis
我们开发了一种方法来找到一个能量最优的刺激，夹带一个合奏的不确定性，解耦的极限环振荡器。此外，当夹带发生时，振荡器之间的相移被约束为小于预定量。这种方法是说明了一个模型ofDrosophilacircadian活动，它比一个标准的24小时光暗周期的表现更好。因为这种方法明确地考虑了给定系统中的不确定性，并且只需要实验可获得的信息，所以它非常适合实验实施，并且最终可以代表被认为是对患有晚期/延迟睡眠期综合征的患者的新治疗。
We develop an approach to find an energy-optimal stimulus that entrains an ensemble of uncertain, uncoupled limit cycle oscillators. Furthermore, when entrainment occurs, the phase shift between oscillators is constrained to be less than a predetermined amount. This approach is illustrated for a model ofDrosophilacircadian activity, for which it performs better than a standard 24-h light-dark cycle. Because this method explicitly accounts for uncertainty in a given system and only requires information that is experimentally obtainable, it is well suited for experimental implementation and could ultimately represent what is believed to be a novel treatment for patients suffering from advanced/delayed sleep-phase syndrome.
影响因子：
3.4
作者：
Pedersen, MG;Bertram, R;Sherman, A
通讯作者：
Sherman, A