In vitro simulation and quantification of wear within the patellofemoral joint replacement
In vitro simulation and quantification of wear within the patellofemoral joint replacement
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DOI：
10.1016/j.jbiomech.2008.02.029
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Fisher, J.
中科院分区：
文献类型：
--
作者：
Ellison, P.;Barton, D. C.;Fisher, J.
体外磨损率的定量现在被认为是在临床试验之前开发新的关节置换术的重要步骤。然而，尽管欧盟每年有超过20万例髌股关节（PFJ）植入，但围绕髌股关节（PFJ）磨损的体外模拟研究很少。开发了一种在实验室中使用全膝关节置换术（TKR）PFJ内的四个输入自由度模拟磨损的方法。通过将体外产生的功能运动学和髌骨表面损伤模式与临床结果进行比较，验证了磨损模拟。该技术已被证明可以以可再现和可重复的方式复制规定的体内运动学。磨痕区域与体内发现的相似。然而，由于蠕变和几何形状的变化，磨损的几何测量是不可靠的。正如之前在胫骨衬垫中发现的那样，磨损体积的几何学测定并不是比较模拟器和回收物磨损的有效方法。通过重量分析计算的体积变化被认为是髌骨磨损的最可重复的体外测量。(c)2008爱思唯尔有限公司保留所有权利。
Quantification of the wear rate in vitro is now considered an essential step in the development of a new joint replacement prior to clinical trials. However, little research exists around in vitro simulation of wear in the patellofemoral joint (PFJ) despite over 200,000 being implanted annually within the European Union. A method to simulate wear in the laboratory using four input degrees of freedom within the PFJ of total knee replacement (TKR) has been developed. Wear simulation was validated through comparison of functional kinematics and patellar surface damage modes produced in vitro to clinical outcomes. The technique has been shown to replicate the prescribed in vivo kinematics in a reproducible and repeatable manner. The wear scar areas were similar to those found in vivo. However, geometrical measurements of wear were not reliable due to creep and geometry changes. As has been found previously with tibial inserts, geometrical determination of wear volume was not found to be an effective method of comparing wear from simulators and retrievals. Change in volume calculated gravimetrically was seen to be the most repeatable measure of patellar wear in vitro. (c) 2008 Elsevier Ltd. All rights reserved.