Aortic valve pathophysiology during left ventricular assist device support
Aortic valve pathophysiology during left ventricular assist device support
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DOI：
10.1016/j.healun.2010.06.006
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发表时间：
2010-12-01
影响因子：
8.9
通讯作者：
May-Newman, Karen
中科院分区：
文献类型：
--
作者：
John, Ranjit;Mantz, Katie;May-Newman, Karen
左心室辅助装置 (LVAD) 增加的适用性和优异的结果彻底改变了晚期心力衰竭患者的可用治疗选择。预先存在的瓣膜异常在该人群中很常见，并且在 LVAD 放置后随后出现瓣膜异常也经常被注意到。虽然在 LVAD 放置之前的心力衰竭患者中，原生二尖瓣和三尖瓣疾病更为常见，但在 LVAD 放置期间和之后，主动脉瓣更有可能在 LVAD 患者中产生异常的病理生理学本次综合综述的目的是回顾 LVAD 患者的主动脉瓣功能，并强调在 LVAD 植入时对患者治疗中预先存在的瓣膜疾病的考虑。将描述 LVAD 植入期间和之后导致瓣膜病理生理学的结构变化的基础，为提高临床理解和预防这些情况的新策略提供基础 J Heart Lung Transplant 2010,29 1321-9 (C) 2010 International Society for Heart and Lung Transplantation All保留权利
The increased applicability and excellent results with left ventricular assist devices (LVADs) have revolutionized the available treatment options for patients with advanced heart failure Pre-existing valve abnor malities are common in this population and subsequent development of valve abnormalities after LVAD placement is also often noted Although native mitral and tricuspid valve disease is more common m heart failure patients before LVAD placement, aortic valves are much more likely to generate abnormal pathophysiology in the LVAD patient during as well as after LVAD placement The aim of this comprehensive review is to review aortic valve function in LVAD patients and highlight the consideration of pre-existing valve disease on patient treatment at the time of LVAD implant The basis for structural changes leading to valve pathophysiology during and after LVAD placement will be described providing a basis for improved clinical understanding and new strategies to prevent these conditions J Heart Lung Transplant 2010,29 1321-9 (C) 2010 International Society for Heart and Lung Transplantation All rights reserved