Differences between chronological and brain age are related to education and self-reported physical activity
Differences between chronological and brain age are related to education and self-reported physical activity
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DOI：
10.1016/j.neurobiolaging.2016.01.014
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发表时间：
2016-04-01
影响因子：
4.2
通讯作者：
Stern, Yaakov
中科院分区：
文献类型：
--
作者：
Steffener, Jason;Habeck, Christian;Stern, Yaakov
本研究调查了教育和体育活动之间的关系，以及生理年龄预测和实际年龄(CA)之间的差异。计算了331名健康成人(年龄19-79岁)的皮质和皮质下灰质区域体积。多变量分析发现脑体积的协方差模式最能预测CA(R2=47%)。这种脑模式的个体表达可作为脑年龄(BA)的生理学测量。通过教育和体力活动自评量表预测CA和BA之间的差异。教育程度和每天爬楼梯次数(FOSC)是BA下降的唯一两个显著预测因素。效应大小表明，每接受一年教育，BA减少0.95年，每天增加1个FOSC，BA减少0.58年。教育和FOSC对区域脑体积的影响在很大程度上是由颞叶和皮质下体积驱动的。这些结果表明，更高的教育水平和每天的FOSC与比CA预测的更大的脑体积有关，这支持了区域灰质体积作为健康脑老化的生物标志物的实用性。(C)2016 Elsevier Inc.保留所有权利。
This study investigated the relationship between education and physical activity and the difference between a physiological prediction of age and chronological age (CA). Cortical and subcortical gray matter regional volumes were calculated from 331 healthy adults (range: 19-79 years). Multivariate analyses identified a covariance pattern of brain volumes best predicting CA (R-2 = 47%). Individual expression of this brain pattern served as a physiologic measure of brain age (BA). The difference between CA and BA was predicted by education and self-report measures of physical activity. Education and the daily number of flights of stairs climbed (FOSC) were the only 2 significant predictors of decreased BA. Effect sizes demonstrated that BA decreased by 0.95 years for each year of education and by 0.58 years for 1 additional FOSC daily. Effects of education and FOSC on regional brain volume were largely driven by temporal and subcortical volumes. These results demonstrate that higher levels of education and daily FOSC are related to larger brain volume than predicted by CA which supports the utility of regional gray matter volume as a biomarker of healthy brain aging. (C) 2016 Elsevier Inc. All rights reserved.