Recent progress on Tourette syndrome.
Recent progress on Tourette syndrome.
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DOI：
10.12703/r/10-70
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Black KJ
中科院分区：
文献类型：
--
作者：
Ueda K;Black KJ
抽动障碍和抽动秽语综合症是儿童最常见的运动障碍，其特征是运动或发声。临床上，抽动秽语综合症经常与合并的精神症状相关。尽管皮质-纹状体-丘脑-皮质回路功能障碍以及神经递质功能异常被认为是抽动的直接原因，但这种关联的机制尚不清楚。最近，通过实验室研究、神经影像学、电生理学测试、环境暴露和基因测试，进行了许多研究来阐明抽动障碍的流行病学、临床病程、共病症状和病理生理学。此外，许多研究人员关注抽动症的治疗，包括行为疗法、药物治疗和手术治疗。在这里，我们概述了抽动秽语综合症的最新进展。
Tic disorders and Tourette syndrome are the most common movement disorders in children and are characterized by movements or vocalizations. Clinically, Tourette syndrome is frequently associated with comorbid psychiatric symptoms. Although dysfunction of cortical–striatal–thalamic–cortical circuits with aberrant neurotransmitter function has been considered the proximate cause of tics, the mechanism underlying this association is unclear. Recently, many studies have been conducted to elucidate the epidemiology, clinical course, comorbid symptoms, and pathophysiology of tic disorders by using laboratory studies, neuroimaging, electrophysiological testing, environmental exposure, and genetic testing. In addition, many researchers have focused on treatment for tics, including behavioral therapy, pharmacological treatment, and surgical treatment. Here, we provide an overview of recent progress on Tourette syndrome.