Relaxation of isolated dog coronary artery induced by propranolol.
Relaxation of isolated dog coronary artery induced by propranolol.
复制标题
普萘洛尔诱导离体狗冠状动脉舒张。
DOI：
10.1016/0014-2999(81)90436-2
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发表时间：
1981
影响因子：
5
通讯作者：
K. Nishi
中科院分区：
文献类型：
--
作者：
M. Sakanashi;K. Nishi
研究了普萘洛尔和阿替洛尔对离体犬钾致冠状动脉收缩的影响。高浓度（3 × 10−5-10−4M）的普萘洛尔可引起冠状动脉条带的松弛，外源性钙离子可恢复或阻止这种松弛。阿替洛尔（10−5 ~ 10 μ m）未改变条带张力。结果表明，心得安可能通过其钙拮抗作用抑制冠状动脉。
The effects of propranolol and atenolol on isolated dog coronary arteries contracted with potassium were investigated in vitro. Propranolol at high concentrations (3 × 10−5-10−4M) produced relaxations of the coronary arterial strips, which were restored or prevented by exogenous calcium ions. Atenolol (10−5-10−4M) never changed the tension of the strips. The results suggest that propranolol may inhibit the coronary arteries through its calcium antagonistic action.