Cytokine-release syndrome: overview and nursing implications.
Cytokine-release syndrome: overview and nursing implications.
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DOI：
10.1188/07.cjon.s1.37-42
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发表时间：
2007-02-01
影响因子：
1.1
通讯作者：
Breslin, Sheila
中科院分区：
文献类型：
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作者：
Breslin, Sheila
细胞因子释放综合征是一种与使用许多单克隆抗体相关的综合征。通常被称为输注反应，它是由抗体靶向的细胞以及募集到该区域的免疫效应细胞释放细胞因子引起的。当细胞因子释放到循环中时，可导致全身症状，如发热、恶心、寒战、低血压、心动过速、虚弱、头痛、皮疹、喉咙发痒和呼吸困难。在大多数患者中，症状的严重程度为轻度至中度，并且易于管理。然而，一些患者可能会经历严重的，危及生命的反应，导致大量释放的细胞因子。在既往未接受过化疗的恶性血液病患者中，首次输注期间更常发生重度反应;重度反应的特点是快速发作和相关症状的严重程度。大量的细胞因子释放是一种肿瘤紧急情况，必须采取特殊的预防措施，以防止危及生命的并发症。本文将概述接受单克隆抗体治疗的患者中尼古丁释放综合征的病因和管理，以更好地准备肿瘤科护士安全地护理此类患者。
Cytokine-release syndrome is a symptom complex associated with the use of many monoclonal antibodies. Commonly referred to as an infusion reaction, it results from the release of cytokines from cells targeted by the antibody as well as immune effector cells recruited to the area. When cytokines are released into the circulation, systemic symptoms such as fever, nausea, chills, hypotension, tachycardia, asthenia, headache, rash, scratchy throat, and dyspnea can result. In most patients, the symptoms are mild to moderate in severity and are managed easily. However, some patients may experience severe, life-threatening reactions that result from massive release of cytokines. Severe reactions occur more commonly during the first infusion in patients with hematologic malignancies who have not received prior chemotherapy; severe reactions are marked by their rapid onset and the acuity of associated symptoms. Massive cytokine release is an oncologic emergency, and special precautions must be taken to prevent life-threatening complications. This article will present an overview of the etiology and management of cytokine-release syndrome in patients receiving monoclonal antibodies to better prepare oncology nurses to safely care for such patients.