OCCURRENCE AND DE-NOVO BIOSYNTHESIS OF FOLLICLE-STIMULATING-HORMONE (FSH) IN BENIGN AND MALIGNANT CONDITIONS OF HUMAN BREAST
OCCURRENCE AND DE-NOVO BIOSYNTHESIS OF FOLLICLE-STIMULATING-HORMONE (FSH) IN BENIGN AND MALIGNANT CONDITIONS OF HUMAN BREAST
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DOI：
10.1016/0304-3835(93)90200-s
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发表时间：
1993-11-30
期刊：
影响因子：
9.7
通讯作者：
SHETH, NA
中科院分区：
文献类型：
--
作者：
GARDE, SV;SHETH, AR;SHETH, NA
我们报告了人类乳房中垂体激素、卵泡刺激素 (FSH) 的发生和生物合成。使用免疫过氧化物酶定位技术，FSH和β-FSH均定位于上皮细胞的细胞质中，但不定位于基质细胞中。与正常样本相比，良性和恶性样本中的免疫染色更加强烈。乳腺组织外植体的体外放射性标记前体实验表明 FSH 是从头合成的。与血清相比，人乳中的 FSH 浓度更高。在性腺中，FSH 参与细胞生长、分化和功能。与正常乳房相比，良性乳腺肿瘤和乳腺癌中存在较高水平的 FSH，这支持了 FSH 可能在乳房恶性转化过程中发挥作用的建议。
We report the occurrence as well as biosynthesis of a Pituitary hormone, follicle stimulating hormone (FSH) in human breast. Using immunoperoxidase localization technique, both FSH and beta-FSH were localized in cytoplasm of epithelial cells but not in stromal cells. Immunostaining was more intense in benign and malignant specimens as compared to normal. In vitro radiolabelled precursor experiments with breast tissue explants indicate de novo synthesis of FSH. Human milk had higher concentrations of FSH as compared to serum. In gonads, FSH is involved in the cellular growth, differentiation and function. The presence of higher levels of FSH in benign mammary tumors and breast cancer when compared to normal breast supports the suggestion that FSH might have a role in the process of breast malignant transformation.