Effects of sensorineural hearing loss and personal hearing aids on cortical event-related potential and behavioral measures of speech-sound processing
Effects of sensorineural hearing loss and personal hearing aids on cortical event-related potential and behavioral measures of speech-sound processing
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DOI：
10.1097/00003446-200504000-00005
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发表时间：
2005-04-01
期刊：
影响因子：
3.7
通讯作者：
Stapells, DR
中科院分区：
文献类型：
--
作者：
Korczak, PA;Kurtzberg, D;Stapells, DR
目的：系统研究感音神经性听力损失和处方个人助听器对皮层事件相关电位（ERP）的联合影响（波N1，MMN，N2 b和P3 b）及其相关的歧视行为措施（d撇灵敏度和反应时间）对在65和80 dB峰-峰等效SPL下呈现的语音/ba/和/da/的响应。设计：皮层ERP被记录到/ba/和/da/语音刺激，在65和80 dB的峰峰值等效SPL从20名听力正常的成年人和14名成人感音神经性听力损失。在1000至2000 Hz的感觉神经损伤的程度范围从中度损失（50至74 dB HQ）到严重的深度损失（75至120 dB HL）。言语刺激中提出了一个古怪的范例和皮层ERPs记录在两个刺激强度的主动和被动听条件。听力障碍的成年人在独立和辅助条件下在每个刺激强度进行测试。电声和真耳测试进行每个主题的助听器（S）电生理测试之前，以确保助听器的功能在testing.Results：个人助听器的使用大大提高了所有的皮层ERP和行为的d-总理性能分数在两个刺激强度的可检测性。这对于患有严重听力损失的人来说尤其如此。在65 dB SPL时，辅助条件下的平均ERP振幅和d-prime敏感性评分均显著高于或优于无辅助条件。在80 dB SPL时，辅助条件下只有N1振幅和d-prime灵敏度评分显著更好。尽管大多数听力受损受试者在辅助条件下表现出振幅增加、潜伏期减少和波形形态更好，但在这些测量中观察到的反应变化（改善）量在受试者之间表现出相当大的变异性。当从正常听力受试者获得的反应相比，听力受损组有显着延长辅助RT laveling在两个刺激强度和N2 b laveling在较高的刺激intensity.Conclusions：这些结果表明，听力受损的人的大脑处理语音刺激具有更大的准确性和更有效的方式，当这些人使用他们的个人助听器。在较低的刺激强度下尤其如此。感音神经性听力损失和个人助听器对皮质ERPs和辨别行为测量的影响取决于感音神经性听力损失的程度、刺激的强度以及反应测量正在评估的皮质听觉处理水平。可能的临床意义，这些皮质ERP和行为的研究结果进行了讨论。
Objective: To systematically investigate the combined effects of sensorineural hearing loss and prescribed personal hearing aid(s) on cortical eventrelated potentials (ERPs) (waves N1, MMN, N2b, and P3b) and their related behavioral measures of discrimination (d-prime sensitivity and reaction time) to the speech sounds /ba/ and /da/ presented at 65 and 80 dB peak-to-peak equivalent SPL.Design: Cortical ERPs were recorded to /ba/ and /da/ speech stimuli presented at 65 and 80 dB peak-topeak equivalent SPL from 20 normal-hearing adults and 14 adults with sensorineural hearing losses. The degree of sensorineural impairment at 1000 to 2000 Hz ranged from moderate losses (50 to 74 dB HQ to severe-profound losses (75 to 120 dB HL). The speech stimuli were presented in an oddball paradigm and cortical ERPs were recorded in both active and passive listening conditions at both stimulus intensities. The adults with hearing impairments were tested in the unaided and aided conditions at each stimulus intensity. Electroacoustic and real-ear testing was performed on each subject's hearing aid(s) before electrophysiology testing to ensure that the hearing aids were functioning at the time of testing.Results: The use of personal hearing aids substantially improved the detectability of all the cortical ERPs and behavioral d-prime performance scores at both stimulus intensities. This was especially true for individuals with severe-profound hearing losses. At 65 dB SPL, mean ERP amplitudes and d-prime sensitivity scores were all significantly higher or better in the aided versus unaided condition. At 80 dB SPL, only the N1 amplitudes and d-prime sensitivity scores were significantly better in the aided condition. Even though the majority of the hearing-impaired subjects showed increased amplitudes, decreased latencies, and better waveform morphology in the aided condition, the amount of response change (improvements) seen in these measures showed considerable variability across subjects. When compared with the responses obtained from the normal-hearing subjects, both hearing-impaired groups had significantly prolonged aided RT latencies at both stimulus intensities and N2b latencies at the higher stimulus intensities.Conclusions: These results suggest that hearing-impaired individuals' brains process speech stimuli with greater accuracy and in a more effective manner when these individuals use their personal hearing aids. This is especially true at the lower stimulus intensity. The effects of sensorineural hearing loss and personal hearing aids on cortical ERPs and behavioral measures of discrimination are dependent on the degree of sensorineural loss, the intensity of the stimuli, and the level of cortical auditory processing that the response measure is assessing. The possible clinical significance of these cortical ERP and behavioral findings is discussed.