Matrix metalloproteinase gene delivery for liver fibrosis.
Matrix metalloproteinase gene delivery for liver fibrosis.
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用于肝纤维化的基质金属蛋白酶基因递送。
DOI：
10.1007/s11095-007-9311-7
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发表时间：
2008-02
影响因子：
3.7
通讯作者：
Brenner, David A.
中科院分区：
文献类型：
--
作者：
Iimuro, Yuji;Brenner, David A.
晚期肝纤维化的解决方案最近已被认为是可能的，如果成功地消除了致病刺激。然而，肝硬化（肝纤维化的终末期）是否能完全消退仍有疑问。在肝脏中递送间质胶原酶，如基质金属蛋白酶（MMP）-1，可能是治疗晚期肝纤维化的有吸引力的策略，因为太少的间质胶原酶和太多的其抑制剂之间的不平衡是纤维化消退的主要障碍。通过递送的间质胶原酶重塑肝细胞外基质还促进活化的肝星状细胞（肝脏中主要的基质产生细胞）的消失，并促进肝细胞的增殖。本综述将重点介绍MMPs基因递送对晚期肝纤维化治疗的影响，同时讨论目前肝纤维化的其他治疗策略，以及开发安全有效的MMPs递送系统的必要性。
The resolution of advanced liver fibrosis has been recently recognized to be possible, if the causative stimuli are successfully removed. However, whether complete resolution from cirrhosis, the end stage of liver fibrosis, can be achieved is still questionable. Delivery of interstitial collagenases, such as matrix metalloproteinase (MMP)-1, in the liver could be an attractive strategy to treat advanced hepatic fibrosis from the view point that the imbalance between too few interstitial collagenases and too many of their inhibitors is the main obstacle to the resolution from fibrosis. Remodeling of hepatic extracellular matrix by delivered interstitial collagenases also facilitates the disappearance of activated hepatic stellate cells, the main matrix-producing cells in the liver, and promotes the proliferation of hepatocytes. This review will focus on the impact of the gene delivery of MMPs for the treatment of advanced liver fibrosis while discussing other current therapeutic strategies for liver fibrosis, and on the need for the development of a safe and effective delivery system of MMPs.
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影响因子：
13.5
作者：
Higashiyama, Reiichi;Inagaki, Yutaka;Okazaki, Isao
通讯作者：
Okazaki, Isao
影响因子：
5
作者：
Borkham-Kamphorst, E;Herrmann, J;Weiskirchen, R
通讯作者：
Weiskirchen, R
DOI：
10.1073/pnas.96.22.12719
发表时间：
1999-10-26
影响因子：
11.1
作者：
George, J;Roulot, D;Bissell, DM
通讯作者：
Bissell, DM
影响因子：
5.1
作者：
Ahmed, A;Keeffe, E B
通讯作者：
Keeffe, E B
影响因子：
2.4
作者：
Arias M;Sauer-Lehnen S;Treptau J;Janoschek N;Theuerkauf I;Buettner R;Gressner AM;Weiskirchen R
通讯作者：
Weiskirchen R