Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.
Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.
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CDK5和p27的低表达与胃癌患者的不良预后相关
DOI：
10.7150/jca.14778
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发表时间：
2016
影响因子：
3.9
通讯作者：
Huang CM
中科院分区：
文献类型：
--
作者：
Sun YQ;Xie JW;Chen PC;Zheng CH;Li P;Wang JB;Lin JX;Lu J;Chen QY;Cao LL;Lin M;Tu RH;Lin Y;Huang CM
先前的几项研究表明，CDK5或p27在胃癌中的表达与总生存期有关。我们曾报道CDK5的抑瘤功能与p27有关。本研究的目的是用免疫组织化学方法研究244例不同CDK5/p27表达状态的胃癌患者的临床病理参数与总生存期的关系。CDK5低表达93例(38.11%)，p27低表达157例(64.34%)。CDK5的表达与性别(P=0.034)和Lauren‘s分级(P=0.013)显著相关。P27的表达与性别(P=0.012)、分化程度(P=0.003)、TNM分期(P=0.013)和淋巴结转移(P=0.001)显著相关。根据CDK5和p27的联合表达，我们将患者分为四种亚型：CDK5低/p27低(n=69)，CDK5高/p27低(n=88)，CDK5低/p27高(n=24)和CDK5高/p27高(n=63)。CDK5低/p27低表达与女性(P=0.026)、弥漫型(P=0.027)和淋巴结转移(P=0.010)密切相关。在Kaplan-Meier分析中，CDK5低/p27低的患者与其他患者相比存活率较低。CDK5高表达和/或p27高表达患者的总体生存率无显著差异。在多因素分析中，CDK5和p27共表达状态被确定为胃癌患者的独立预后因素。
Several previous studies have demonstrated that CDK5 or p27 expression in gastric cancer are associated with overall survival. We have previously reported that tumor suppressive function of CDK5 is related to p27. The aim of this study was to investigate correlation between the clinicopathological parameters and overall survival with different CDK5/p27 expression statuses in 244 gastric cancer patients using immunohistochemistry. Low CDK5 expression was detected in 93 cases (38.11%) and low p27 in 157 cases (64.34%). The expression of CDK5 was significantly related to sex (P = 0.034) and Lauren's classification (P = 0.013). The expression of p27 was significantly related to sex (P = 0.012), differentiation (P = 0.003), TNM stage (P = 0.013) and lymph node metastasis (P = 0.001). Based on the combined expression of CDK5 and p27, we classified the patients into four subtypes: CDK5 Low/p27 Low (n = 69), CDK5 High/p27 Low (n = 88), CDK5 Low/p27 High (n = 24) and CDK5 High/p27 High (n = 63). The CDK5 Low/p27 Low expression was closely related to female (P = 0.026), diffuse type (P = 0.027) and lymph node metastasis (P = 0.010). The CDK5 Low/p27 Low patients displayed poorer survival in comparison with the rest of the patients in Kaplan-Meier analysis. No significant overall survival difference was observed among the patients with CDK5 High and/or p27 High expression. In the multivariate analysis, CDK5 and p27 co-expression status was identified as an independent prognostic factor for patients with gastric cancer.