Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele
Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele
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DOI：
10.1016/j.tet.2006.01.099
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发表时间：
2006-04-10
期刊：
影响因子：
2.1
通讯作者：
Higa, T
中科院分区：
文献类型：
--
作者：
Tanaka, C;Tanaka, J;Higa, T
六个新的缩肽，seragamides A-F（1-6），和一个已知的geodiaminase I（7）已被分离作为细胞毒性代谢产物从冲绳海绵Suberites E.E.通过波谱分析和化学转化方法鉴定了它们的结构。丝氨酰胺A（1）促进G-肌动蛋白的聚合并稳定F-肌动蛋白丝。(c)2006爱思唯尔有限公司版权所有。
Six new depsipeptides, seragamides A-F (1-6), and a known geodiamolide I (7) have been isolated as cytotoxic metabolites from the Okinawan sponge Suberites japonicus. Their structures were elucidated by means of spectroscopic analysis and chemical transformations. Seragamide A (1) promotes the polymerization of G-actin and stabilizes F-actin filaments. (c) 2006 Elsevier Ltd. All rights reserved.