COMPUTER-BASED CHARACTERIZATION OF EPIDERMAL GROWTH-FACTOR PRECURSOR
COMPUTER-BASED CHARACTERIZATION OF EPIDERMAL GROWTH-FACTOR PRECURSOR
复制标题
DOI：
10.1038/307558a0
复制
发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
JOHNSON, MS
中科院分区：
文献类型：
--
作者：
DOOLITTLE, RF;FENG, DF;JOHNSON, MS
小鼠表皮生长因子（EGFP）的前体的cDNA序列最近已被两个groups1，2，他们都注意到存在重复的相似片段，每个约40个残基长。这些重复单元之一与表皮生长因子本身的序列重叠。据报道，表皮生长因子的序列与胰腺分泌型胰蛋白酶3（PSTI）的序列相似，并且发现与牛因子X4（一种血液生长因子）的部分序列更匹配。我们在这里报告，有一个甚至更强的相似性之间的序列的一些重复单位的表皮生长因子前体和某些片段的因子X。这种序列相似性在与其他凝血因子的比较中也是明显的。在这些序列比较的基础上，我们提出了表皮生长因子前体的进化方案。我们还确定了前体序列中的某些结构特征，这些结构特征与成熟表皮生长因子的产生方式有关。
The cDNA sequence of the precursor of mouse epidermal growth factor (EGFP) has recently been reported by two groups1,2, both of whom noted the presence of repeated similar segments, each about 40 residues long. One of these repeat units overlaps with the sequence of epidermal growth factor itself. The sequence of epidermal growth factor has been reported to be similar to that of pancreatic secretory trypsin inhibitor3(PSTI) and a somewhat better match has been found with part of the sequence of bovine factor X4, one of the blood coagulating factors. We report here that there is an even stronger similarity between the sequences of some of the repeat units of epidermal growth factor precursor and certain segments in factor X. This sequence similarity is also apparent in comparisons with other blood coagulation factors. On the basis of these sequence comparisons we suggest a scheme for the evolution of the epidermal growth factor precursor. We have also identified certain structural features in the precursor sequence that bear on the way in which the mature epidermal growth factor is generated.