Return of elevated blood pressure after withdrawal of antihypertensive drugs.
Return of elevated blood pressure after withdrawal of antihypertensive drugs.
复制标题
停药后血压再次升高。
DOI：
10.1161/01.cir.51.6.1107
复制
发表时间：
1975
期刊：
影响因子：
37.8
通讯作者：
L. Wilkins
中科院分区：
文献类型：
--
作者：
L. Wilkins
对 86 名接受氢氯噻嗪、利血平和肼屈嗪治疗两年或更长时间且最后一年治疗平均舒张压低于 96 mm Hg 的高血压患者进行了研究，研究了停止积极治疗后动脉压上升的速度。 60 名患者被分配双盲服用安慰剂，26 名患者继续服用活性药物。在 18 个月的随访中，安慰剂组中有 42 名患者因血压升高而被移除，其中 39 名患者在前 6 个月内被移除。安慰剂组有 6 名患者，治疗组没有一名患者因发病事件而被移除。 9% 或 15% 的安慰剂患者血压保持正常。安慰剂组的动脉压上升率似乎与开始积极治疗前的血压高度直接相关，而与患者的年龄成反比。停止积极治疗后，血清尿酸显着下降，而血清钾显着升高。葡萄糖耐量试验略微向正常方向变化，而血清肌酐未显示显着变化。
The rate at which arterial pressure rises after discontinuing active treatment was investigated in a group of 86 hypertensive patients who received treatment with hydrochlorothiazide, reserpine and hydralazine for two years or longer and whose diastolic pressures averaged below 96 mm Hg for the last year of treatment. Sixty patients were assigned double-blind to placebos and 26 were continued on active drugs. Forty-two of the placebo group of patients were removed over an 18 month follow-up because of return of elevated blood pressures, 39 being removed in the first six months. Six patients in the placebo group and none in the treated group were removed because of morbid events. Nine or 15% of the placebo patients remained normotensive. The rate of rise in arterial pressure in the placebo group appeared to be related directly to the height of the pressure prior to initiation of active treatment and inversely to the age of the patients. Serum uric acid fell significantly while serum potassium rose significantly after active treatment was discontinued. The glucose tolerance test changed slightly in a direction toward normal while serum creatinine showed no significant change.