Antimicrobial performance of nanostructured silica-titania sieves loaded with izohidrafural against microbial strains isolated from urinary tract infections
Antimicrobial performance of nanostructured silica-titania sieves loaded with izohidrafural against microbial strains isolated from urinary tract infections
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DOI：
10.1016/j.crci.2016.09.007
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发表时间：
2017-05-01
影响因子：
1.6
通讯作者：
Meghea, Aurelia
中科院分区：
文献类型：
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作者：
Al Tameemi, Mustafa Basim M.;Stan, Raluca;Meghea, Aurelia
本研究旨在通过生物定量检测，考察以二氧化硅-二氧化钛为代表的新型生物活性纳米结构作为新型抗菌剂偶氮呋喃的载体对医院内尿路感染分离菌株的抑制效果。已经建立了几个释放试验，并与MCM-41进行了平行实验比较，以获得最佳释放曲线。所获得的体系表明，负载偶氮呋喃甲醛的二氧化硅筛对肺炎克雷伯菌(平均最低抑菌浓度40.62mU/m L)、脱氨酶阳性菌株(平均最低抑菌浓度2.925 mU/m L)和奇异变形杆菌(平均9.37m U/m L)具有最强的抗菌活性，最后一种细菌在导尿管中的生长速度最高。相比之下，未负载的硅钛筛对革兰氏阳性球菌表现出最高的抗菌活性。异硫氰醛的抑菌效果最好，优于常用药物呋喃妥因，平均MIC为4.68mU g/m L。(C)2016年科学院。爱思唯尔·马森公司出版。版权所有。
This study aimed to examine the efficiency of novel bioactive nanostructures represented by silica-titania sieves used as carriers for a new antibacterial agent izohidrafural against bacterial strains isolated from nosocomial urinary tract infections, by using biological quantitative assays. Several release trials have been established and compared with MCM-41 in parallel experiments to achieve the optimum release profile. The obtained systems showed that silica-titania sieves loaded with izohidrafural proved to be the most active material against Klebsiella pneumoniae (average minimal inhibitory concentration [MIC] 40.62 mu g/mL), desaminase-positive strains (average MIC 2.925 mu g/mL), and Proteus mirabilis (average MIC 9.37 mu g/mL), the last being reported with the highest growth rate in the urinary tract catheters. In contrast, the nonloaded silica titanium sieves exhibited the highest antimicrobial activity against the Gram-positive cocci. Izohidrafural exhibited the highest antimicrobial efficiency, superior to the common drug nitrofurantoin against most Escherichia coli strains, with average MIC of 4.68 mu g/mL. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.