Organocatalysis mediated by (thio)urea derivatives
Organocatalysis mediated by (thio)urea derivatives
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DOI：
10.1002/chem.200501076
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发表时间：
2006-07-17
影响因子：
4.3
通讯作者：
Connon, Stephen J.
中科院分区：
文献类型：
--
作者：
Connon, Stephen J.
在过去的十年中，N,N-二烷基（硫代）脲衍生物作为活性无金属有机催化剂用于易受一般酸催化影响的各种合成有用的反应的潜力已经开始被认识到。本文描绘了这些催化剂的发展（重点是所涉及的设计原理），从早期的“概念验证”材料到当代高选择性不对称转化的活性手性（双功能）促进剂。
Over the last decade the potential for N,N-dialkyl(thio)urea derivatives to serve as active metal-free organocatalysts for a wide range of synthetically useful reactions susceptible to the influence of general acid catalysis has begun to be realised. This article charts the development of these catalysts (with emphasis on the design principles involved), from early "proof-of-concept" materials to contemporary active chiral (bifunctional) promoters of highly selective asymmetr.c transformations.