Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora
Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora
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长链单不饱和脂肪酸通过改变微生物菌群来改善内皮功能
DOI：
10.1016/j.trsl.2021.03.016
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发表时间：
2021
影响因子：
7.8
通讯作者：
Sata Masataka
中科院分区：
文献类型：
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作者：
Tsutsumi Rie;Yamasaki Yuki;Takeo Jiro;Miyahara Hiroko;Sebe Mayu;Bando Masahiro;Tanba Yousuke;Mishima Yuna;Takeji Kana;Ueshima Nanako;Kuroda Masashi;Masumoto Saeko;Harada Nagakatsu;Fukuda Daiju;Yoshimoto Ryoko;Tsutsumi Yasuo M;Aihara Ken-ichi;Sata Masataka
碳链长度超过18个单位的鱼油衍生长链单不饱和脂肪酸（LCMUFA）可改善小鼠的心血管风险。在这项研究中，我们研究了LCMUFAs是否可以改善小鼠和人类的内皮功能。在一项双盲、随机、安慰剂对照、平行组、多中心研究中，健康受试者被随机分配到LCMUFA油（秋刀鱼油）或对照油（橄榄油和金枪鱼油）组。入组60例受试者，每种油给药4周。在动物研究中，ApoE−/−小鼠喂食西方饮食，补充3%的顺丁烯二酸（C20：1）或鲸蜡油酸（C22：1），持续12周。来自LCMUFA组的参与者显示出内皮功能的改善和较低的三甲胺-N-氧化物水平，这是冠状动脉疾病的预测因子。C20：1和C22：1油显著改善动脉粥样硬化病变和几种炎性细胞因子（包括IL-6和TNF-α）的血浆水平。这些有益效果与肠道微生物群环境的改善一致，如从厚壁菌门和/或拟杆菌门的比例降低、阿克曼氏菌丰度增加以及短链脂肪酸（SCFA）诱导的胰高血糖素样肽-1（GLP-1）表达和血清GLP-1水平上调所证明的。这些数据表明，LCMUFA改变了刺激SCFA产生的微生物群环境，导致GLP-1分泌的诱导。因此，鱼油衍生的长链单不饱和脂肪酸可能有助于预防心血管疾病。
Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE−/−mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance ofAkkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.