The characteristics of relapse in adult-onset minimal-change nephrotic syndrome.
The characteristics of relapse in adult-onset minimal-change nephrotic syndrome.
复制标题
DOI：
10.1007/s10157-007-0484-5
复制
发表时间：
2007-09-01
影响因子：
2.3
通讯作者：
Nitta, Kosaku
中科院分区：
文献类型：
--
作者：
Takei, Takashi;Koike, Minako;Nitta, Kosaku
背景技术背景：虽然微小病变型肾病综合征（MCNS）对类固醇高度敏感，但某些患者复发的频率很高，需要重复使用高剂量的泼尼松龙。因此，有必要确定的因素，可以预测这种复发的风险增加，在一些患者，以建立有用的治疗方法，以减少risk.METHODS：为了澄清的因素，可能会增加复发的风险，82例日本成人MCNS患者接受治疗，在我们的部门进行了回顾性分析。其中，55例患者（67.1%）在显示初始缓解后复发。将患者分为未复发组（n = 27）和复发组（n = 55），比较两组患者的临床病理生理特征。（P = 0.0002）和类固醇副作用的频率增加，观察复发组相比，nonrecurrence group.要发展有效的治疗模式，重要的是要有一个彻底的了解MCNS患者的临床病理生理特征显示复发。
BACKGROUND: Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk.METHODS: To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico-pathophysiological characteristics between the two groups.RESULTS: Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group.CONCLUSIONS: To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.