Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium
Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium
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DOI：
10.1128/jb.186.14.4808-4812.2004
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Fischetti, VA
中科院分区：
文献类型：
--
作者：
Yoong, P;Schuch, R;Fischetti, VA
粪肠球菌和屎肠球菌感染由于对抗生素的高水平耐药性而越来越难以治疗。PlyV12是一种噬菌体裂解酶，被分离并显示出有效地杀死E.粪肠球菌E.屎肠菌（包括万古霉素耐药菌株）以及其他人类病原体。我们建议将其开发和使用作为一种替代治疗工具。
Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool.