Cumulative incidence of tuberculosis in lung cancer patients in Japan: A 6-year observational study
Cumulative incidence of tuberculosis in lung cancer patients in Japan: A 6-year observational study
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DOI：
10.1016/j.resinv.2015.11.001
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发表时间：
2016-05-01
影响因子：
3.1
通讯作者：
Suda, Takafumi
中科院分区：
文献类型：
--
作者：
Suzuki, Yuzo;Imokawa, Shiro;Suda, Takafumi
背景资料：结核病（TB）仍然是世界范围内的健康相关问题，已知某些恶性肿瘤与TB风险增加有关。肺癌是癌症相关死亡的主要原因，据报道肺癌患者的数量一直在增加。由于肺癌的预后仍然很差，因此采用了积极的综合治疗。癌症本身引起的免疫抑制和治疗相关的免疫调节可能会增加结核病的风险。本研究旨在调查肺癌患者肺结核的累积发病率。方法：本观察性研究包括2007年3月至2013年3月诊断为肺癌的904例连续患者，并随访至2015年3月（平均25.2个月）。结果：9例肺癌患者（1.00%）在观察期内发生结核病。在所有病例中，结核病均发生在肺癌诊断后2年内。6个月、1年和2年的结核累积发病率分别为0.65%、1.15%和1.38%.Conclusions：日本肺癌患者结核累积发病率为1.38%。(C)2015日本呼吸学会Elsevier B.V.出版，保留所有权利。
Background: Tuberculosis (TB) remains a health-related problem worldwide, and certain malignancies are known to be associated with an increased risk of TB. Lung cancer is the leading cause of cancer-related death, and the number of patients with lung cancer has been reportedly increasing. As the prognosis of lung cancer remains poor, aggressive comprehensive therapies have been used. The immunosuppression caused by cancer itself and treatment-associated immune modulation may increase the risk of TB. The present study was conducted to investigate the cumulative incidence of TB in lung cancer patients.Methods: This observational study included 904 consecutive patients diagnosed with histologically confirmed lung cancer from March 2007 to March 2013 and followed until March 2015 (mean 25.2 months). The cumulative incidence of TB was estimated using the Kaplan-Meier method.Results: Nine lung cancer patients (1.00%) developed TB during the observation period. In all cases, TB occurred within 2 years of the diagnosis of lung cancer. The cumulative incidence of TB at 6 months, 1 year, and 2 years was 0.65%, 1.15%, and 1.38%, respectively.Conclusions: The cumulative incidence of TB in lung cancer patients was 1.38% in Japan. (C) 2015 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.