Infection with Strongyloides venezuelensis Induces Transient Airway Eosinophilic Inflammation, an Increase in Immunoglobulin E, and Hyperresponsiveness in Rats
Infection with Strongyloides venezuelensis Induces Transient Airway Eosinophilic Inflammation, an Increase in Immunoglobulin E, and Hyperresponsiveness in Rats
复制标题
委内瑞拉类圆线虫感染可诱发大鼠短暂性气道嗜酸性粒细胞炎症、免疫球蛋白 E 增加和高反应性
作者：
M. Silveira;K. Nunes;D. C. Cara;D. Souza;A. Corrêa;M. Teixeira;D. Negrão
摘要在生命周期中通过肺部迁移的线虫寄生虫感染和过敏性哮喘是人类的两种高度流行的疾病;因此，可以预期两者可能同时发生。Th 2淋巴细胞在控制寄生虫消除的机制中以及在哮喘肺中观察到的病理学中具有主导和重要的作用。这种情况的后果已经探讨，有争议的结果，证明发展的实验模型，其中过敏性气道炎症和蠕虫感染之间的关系可能进行评估。本研究描述了单次（皮下接种1,500只L3幼虫）或多次（每周5次皮下接种1,500只L3幼虫）委内瑞拉圆线虫感染后大鼠肺部发生的炎症、体液和功能变化。结果表明，S.委内瑞拉幼虫通过感染大鼠的肺诱导局部嗜酸性炎症过程，对于单次感染的大鼠，该过程主要是局灶性和实质性的，并且在多次感染后是支气管周围的。炎症过程伴随着粘液分泌过多、支气管上皮和肌肉层增厚以及免疫球蛋白E浓度的局部增加，其在5至7天后达到峰值，并在单次或多次感染12天后消退。在感染大鼠中观察到的肺免疫病理学变化的峰值与肺气道高反应性（AHR）一致，这是哮喘的关键功能改变。我们建议，这个实验模型是理想的，进行进一步的研究，对线虫感染的免疫保护与过敏性气道炎症的免疫病理学。
ABSTRACT Infection by nematode parasites with a pulmonary migration in their life cycle and allergic asthma are two highly prevalent diseases in humans; therefore, one may expect both may occur concomitantly. There is a predominant and essential role of Th2 lymphocytes in the mechanisms underlying the control of parasite elimination as well as in the pathology observed in the asthmatic lung. The consequences of such situations have been explored, with controversial results, justifying the development of experimental models in which the relationship between allergic airway inflammation and helminth infection might be evaluated. The present work describes the inflammatory, humoral, and functional changes that occur in the lung of rats after single (subcutaneous inoculation of 1,500 L3 larvae) or multiple (five weekly subcutaneous inoculations of 1,500 L3 larvae) Strongyloides venezuelensis infections. The results show that the migration of S. venezuelensis larvae through the lungs of infected rats induces a local eosinophilic inflammation process which is mostly focal and parenchymal for rats infected a single time and which is peribronchial after multiple infections. The inflammatory process is accompanied by mucus hypersecretion, thickening of bronchial epithelial and muscle layers, and local increase in immunoglobulin E concentrations that peak after 5 to 7 days and are resolved after 12 days of single or multiple infections. The peak of lung immunopathologic changes observed in infected rats coincides with lung airway hyperresponsiveness (AHR), a key functional alteration in asthma. We propose that this experimental model is ideal to carry out further studies on immunoprotection against nematode infection versus immunopathology of allergic airway inflammation.
登录
查看更多内容
针对大鼠 IgE Fc 和 Fab 区域的两种单克隆抗体的特性。
DOI：
10.1159/000233347
发表时间：
1983
期刊：
International archives of allergy and applied immunology
影响因子：
--
作者：
Conrad,DH;Studer,E;Gervasoni,J;Mohanakumar,T
通讯作者：
Mohanakumar,T
DOI：
10.1165/ajrcmb.16.4.9115759
发表时间：
1997-04-01
影响因子：
6.4
作者：
Temann, UA;Prasad, B;Rankin, JA
通讯作者：
Rankin, JA
Interleukin-1 是一种粘液分泌促进剂。
影响因子：
4.3
作者：
Cohan,VL;Scott,AL;Dinarello,CA;Prendergast,RA
通讯作者：
Prendergast,RA
白细胞介素 5 和嗜酸性粒细胞在蠕虫引起的气道高反应性中发挥重要作用。
影响因子：
3.1
作者：
Hall,LR;Mehlotra,RK;Higgins,AW;Haxhiu,MA;Pearlman,E
通讯作者：
Pearlman,E
大鼠肠粘膜组织中B淋巴细胞的快速抗蠕虫反应。
DOI：
10.1006/cimm.1999.1474
发表时间：
1999
期刊：
Cellular immunology.
影响因子：
--
作者：
Wang,CH;Richards,EM;Bell,RG
通讯作者：
Bell,RG