ABC Transporters, Drug Resistance, and Cancer Stem Cells
ABC Transporters, Drug Resistance, and Cancer Stem Cells
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DOI：
10.1007/s10911-009-9109-9
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Dean, Michael
中科院分区：
文献类型：
--
作者：
Dean, Michael
保护人体干细胞不受毒素的破坏或死亡是有机体的一项关键功能，因为干细胞需要在有机体的整个生命周期中保持完好。保护干细胞的主要机制之一是通过表达三磷酸腺苷结合盒(ABC)基因家族的多功能外排转运蛋白。这些转运蛋白在肿瘤细胞的多药耐药中也发挥了作用，这一点已被人们所知超过25年。癌症干细胞概念的一个令人兴奋的结果是，肿瘤启动细胞可能天生对许多标准疗法具有抵抗力。这提供了一种机制，癌症干细胞可以在细胞毒或靶向治疗中幸存下来，并导致肿瘤重新生长或复发。因此，更好地了解干细胞对化疗耐药的机制可能会带来新的治疗靶点和更好的抗癌策略。
The protection of the body's stem cells from damage or death due to toxins is a critical function of an organism, as the stem cells need to remain intact for the entire life of the organism. One of the principal mechanisms for protecting stem cells is through the expression of multifunctional efflux transporters from the ATP-binding cassette (ABC) gene family. These same transporters have been known for over 25 years to also play a role in multidrug resistance of tumor cells. An exciting outcome of the concept of the cancer stem cell is that the tumor initiating cell may be innately resistant to many standard therapies. This provides one mechanism in which cancer stem cells could survive cytotoxic or targeted therapies and lead to tumor regrowth or relapse. Gaining a better insight into the mechanisms of stem cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anti-cancer strategies.