Oral Vaccine Development by Molecular Display Methods Using Microbial Cells
Oral Vaccine Development by Molecular Display Methods Using Microbial Cells
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DOI：
10.1007/978-1-4939-3389-1_32
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Ueda, Mitsuyoshi
中科院分区：
文献类型：
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作者：
Shibasaki, Seiji;Ueda, Mitsuyoshi
口服疫苗比注射疫苗更容易施用。为了使用疫苗诱导充分的免疫反应，抗原蛋白通常与佐剂材料结合。本章介绍了使用分子展示技术设计口服疫苗的方法。在分子展示技术中，抗原蛋白被展示在具有佐剂能力的微生物细胞表面。当有效抗原蛋白的DNA序列可用时，这项技术将为生产口服疫苗提供一种相当方便的方法。例如，使用两种不同的分子展示系统（酿酒酵母和干酪乳杆菌）引入了针对念珠菌病的口服疫苗。
Oral vaccines are easier to administer than injectable vaccines. To induce an adequate immune response using vaccines, antigenic proteins are usually combined with adjuvant materials. This chapter presents methodologies for the design of oral vaccines using molecular display technology. In molecular display technology, antigenic proteins are displayed on a microbial cell surface with adjuvant ability. This technology would provide a quite convenient process to produce oral vaccines when the DNA sequence of an efficient antigenic protein is available. As an example, oral vaccines against candidiasis were introduced using two different molecular display systems with Saccharomyces cerevisiae and Lactobacillus casei.