A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry
A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry
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DOI：
10.1039/c2ay05741g
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发表时间：
2012-02-01
影响因子：
3.1
通讯作者：
Zhang, Xin-Xiang
中科院分区：
文献类型：
--
作者：
Tie, Cai;Zhang, Xin-Xiang
本工作设计并开发了一种新型的多电荷标记剂，用于毛细管电泳质谱(CE-MS)分析。用这种试剂标记的葡聚糖有多个电荷。结果表明，多聚糖的分离效率得到了提高，大分子多聚糖的灵敏度提高了10倍以上。
In this work, a novel labelling reagent with multi-charges was designed and developed for glycans capillary electrophoresis-mass spectrometry (CE-MS) analysis. Glycans labelled with this reagent have multiple charges. The results showed that the separation efficiencies of glycans were improved and the sensitivities of large glycans were enhanced more than 10 fold.