VARIATION MAINTAINED IN QUANTITATIVE TRAITS WITH MUTATION SELECTION BALANCE - PLEIOTROPIC SIDE-EFFECTS ON FITNESS TRAITS
VARIATION MAINTAINED IN QUANTITATIVE TRAITS WITH MUTATION SELECTION BALANCE - PLEIOTROPIC SIDE-EFFECTS ON FITNESS TRAITS
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DOI：
10.1098/rspb.1990.0110
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发表时间：
1990-11-22
影响因子：
4.7
通讯作者：
HILL, WG
中科院分区：
文献类型：
--
作者：
KEIGHTLEY, PD;HILL, WG
研究了数量性状遗传变异的模型，其中影响该性状的突变也对适应性产生有害的多效性影响，使得突变体的影响呈双变量分布。它的主要动机是频繁观察到可见突变的有害副作用。当突变体对性状和适应度的影响的绝对值的相关性ρ为统一时，该模型的行为类似于仅对性状进行纯稳定选择的模型，并且随着种群规模（N）的增加，遗传方差迅速增加到极限。否则（ρ < 1），遗传方差随着 N 的增加而继续增加，但可能会非常缓慢，因为影响度量性状的基因在适应度方面几乎是中性的，因此在大群体中贡献很大的方差。该模型预测，由于极端基因型往往不太适合，因此度量性状似乎处于稳定选择之下，并且评估了其表观强度。
A model of genetic variation in a quantitative trait is investigated in which mutations affecting the trait also have deleterious pleiotropic effects on fitness, such that there is a bivariate distribution of effects of the mutants. It is motivated principally by frequent observations of deleterious side-effects of visible mutations. When the correlation, .rho., of absolute values of mutant effects on the trait and fitness is unity, the model behaves similarly to one of pure stabilizing selection on the trait alone, and the genetic variance quickly increases to a limit with increasing population size (N). Otherwise (.rho. < 1), the genetic variance continues to increase as N increases, but may do so very slowly because genes affecting the metric trait can be nearly neutral with respect to fitness and therefore contribute much variance in large populations. The model predicts that the metric trait will appear to be under stabilizing selection because extreme genotypes tend to be less fit, and its apparent strength is evaluated.