Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction?
Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction?
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血小板激活因子：生殖植入前阶段的旁分泌因子？
DOI：
10.1095/biolreprod40.5.907
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发表时间：
1989
影响因子：
3.6
通讯作者：
Harper,MJ
中科院分区：
文献类型：
--
作者：
Harper,MJ
血小板激活因子 (PAF) 通过激活多种组织（包括下丘脑和子宫内膜）中的特定膜结合位点发挥作用。 PAF 已在多种生殖组织（即胚胎、卵巢、子宫和精子）中被发现。在子宫中，PAF 水平受激素控制，黄体酮和前列腺素 E2 (PGE2) 会升高 PAF 水平。 PAF 拮抗剂会干扰精子功能、排卵和着床。现有证据表明 PAF 可能是生殖过程中重要的生理调节因子。
Platelet-activating factor (PAF) exerts its actions through activation of specific membrane binding sites found in a variety of tissues, including hypothalamus and endometrium. PAF has been identified in several reproductive tissues (i.e. embryo, ovary, uterus, and spermatozoon). In the uterus, PAF levels are hormonally controlled, being elevated by progesterone and prostaglandin E2(PGE2). Antagonists of PAF interfere with sperm function, ovulation, and implantation. The available evidence suggests that PAF may be an important physiological regulator in reproduction.