Fabrication of size-controllable nanofluidic channels by nanoimprinting and its application for DNA stretching
Fabrication of size-controllable nanofluidic channels by nanoimprinting and its application for DNA stretching
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DOI：
10.1021/nl034877i
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发表时间：
2004-01-01
期刊：
影响因子：
10.8
通讯作者：
Chou, CF
中科院分区：
文献类型：
--
作者：
Guo, LJ;Cheng, X;Chou, CF
我们报告了一种新的方法，大大简化了纳米流体通道的制造，具有良好的控制尺寸。它是通过将通道模板压印到玻璃盖板上的薄聚合物薄膜上而实现的，这比以前的方法提供了更高的吞吐量。我们在这些纳米通道中展示了有效的DNA拉伸。该方法为低成本制备纳米流体通道提供了一种简单实用的解决方案，可作为纳米尺度化学分析系统的有用工具。
We report a new approach to greatly simplify the fabrication of nanofluidic channels with well-controlled dimensions. It is achieved by imprinting a channel template into a thin polymer film cast on a glass cover slip in a single step, offering a much higher throughput than previous methods. We demonstrated effective DNA stretching in these nanochannels. This method provides a simple and practical solution for low-cost fabrication of nanofluidic channels, which may serve as a useful tool for chemical analysis system on the nanoscale.