Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver
Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver
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喂养大鼠中链甘油三酯和番茄粉可增加肝脏番茄红素含量并减少肝脏中脂质代谢相关基因的表达
DOI：
10.1021/acsfoodscitech.0c00155
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Mochizuki Kazuki
中科院分区：
文献类型：
--
作者：
Kimura Mayu;Tamura Sayaka;Ishiyama Shiori;Mochizuki Kazuki
番茄红素能有效抑制活性氧，但由于其高脂溶性，其生物利用度较低。在这里，我们评估了喂食中链甘油三酯(MCTs)和番茄粉(T)是否影响肝脏中番茄红素的积累和代谢。中链甘油三酯(MCTs)促进脂溶食物成分的乳化，并且比长链甘油三酯(LCTs)代谢更快。MCT+T组大鼠肝脏番茄红素含量高于LCT+T组。MCT+T组大鼠血清高分子脂联素水平明显高于其他组。与LCT+T饲喂大鼠相比，MCT+T饲喂大鼠肝脏甘油三酯降低。此外，MCT+T组大鼠肝脏中AcacaA和Scd1mRNA的表达水平显著低于MCT+T组，提示MCT和T可提高肝脏番茄红素含量和全身性胰岛素敏感性，改善肝脏脂质代谢。
Lycopene quenches reactive oxygen species effectively; however, its bioavailability is low owing to its high lipid solubility. Here, we assessed whether feeding Sprague–Dawley rats medium-chain triglycerides (MCTs), which promote the emulsification of lipid-soluble food components and are metabolized more rapidly than long-chain triglycerides (LCTs), along with tomato powder (T) affects lycopene accumulation and metabolism in the liver. Liver lycopene contents were higher in MCT+T-fed rats than in LCT+T-fed rats. Serum levels of high molecular weight adiponectin were markedly higher in MCT+T-fed rats than in the other groups. MCT+T-fed rats exhibited lower liver triglycerides compared with LCT+T-fed rats. Furthermore, the elevatedAcacaandScd1mRNA expression levels observed in rats fed MCTs were decreased in rats fed MCT+T. These results suggest that feeding rats MCTs and T increased the liver lycopene content and systemic insulin sensitivity, improving lipid metabolism in the liver.
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影响因子：
3.7
作者：
Kim YI;Hirai S;Goto T;Ohyane C;Takahashi H;Tsugane T;Konishi C;Fujii T;Inai S;Iijima Y;Aoki K;Shibata D;Takahashi N;Kawada T
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Kawada T
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影响因子：
2.4
作者：
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H. García
db/db 小鼠的短期热量限制可改善心肌功能并增加高分子量 (HMW) 脂联素。
DOI：
10.1016/j.ijcme.2016.10.002
发表时间：
2016
期刊：
IJC metabolic & endocrine
影响因子：
--
作者：
Xu,XJulia;Babo,Erma;Qin,Fuzhong;Croteau,Dominique;Colucci,WilsonS
通讯作者：
Colucci,WilsonS
膳食饱和脂肪酸类型影响肥胖引起的代谢功能障碍和小鼠血浆脂质组学特征。
DOI：
10.1016/j.jnutbio.2018.10.005
发表时间：
2019
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
P. Žáček;M. Bukowski;A. Mehus;L. Johnson;Huawei Zeng;S. Raatz;J. Idso;M. Picklo
通讯作者：
M. Picklo
影响因子：
4.1
作者：
Hasan, Naser M. Y.
通讯作者：
Hasan, Naser M. Y.