Pancreatic Steatosis Demonstrated at MR Imaging in the General Population: Clinical Relevance
Pancreatic Steatosis Demonstrated at MR Imaging in the General Population: Clinical Relevance
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DOI：
10.1148/radiol.15140446
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发表时间：
2015-07-01
期刊：
影响因子：
19.7
通讯作者：
Meffert, Peter J.
中科院分区：
文献类型：
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作者：
Kuehn, Jens-Peter;Berthold, Friederike;Meffert, Peter J.
目的：为了确定胰腺脂肪含量和2型糖尿病和前驱diabetes.Materials和方法之间的关系：从前瞻性人群为基础的研究健康在波美拉尼亚（SHIP），1367名志愿者（563名男性，678名女性;中位年龄，50岁）进行全身磁共振（MR）成像在1.5 T，其中包括多回波化学位移编码采集腹部。SHIP由机构审查委员会批准，并获得所有参与者的书面知情同意书。质子密度脂肪分数（PDFF）计算后校正T1偏差，T2* 偏差，脂肪的多峰光谱复杂性，和噪声偏差。根据口服葡萄糖耐量试验结果，将参与者分为葡萄糖耐量正常者（n = 740）、糖尿病前期患者（n = 431）和确诊2型糖尿病但未用药的患者（n = 70）。在胰头、胰体和胰尾中评估PDFF。采用多变量回归分析研究PDFF与人口统计学因素、行为因素和与代谢综合征相关的实验室数据之间的可能关系。结果：在所有受试者中，平均未经校正的胰腺脂肪含量为4.4%（头部，4.6%;身体，4.9%;尾部，3.9%;不均匀分布，P <0.001）。在糖耐量正常、糖尿病前期和2型糖尿病受试者中，胰腺PDFF无显著差异（P = 0.980）。胰腺PDFF与年龄和体重指数呈正相关，与血清脂肪酶活性呈负相关（P <0.001）。结论：胰腺脂肪的存在与糖尿病前期或糖尿病无关，这表明它与个体的血糖状态几乎没有临床相关性。
Purpose: To determine the relationship between pancreatic fat content and type 2 diabetes and prediabetes.Materials and Methods: From the prospective population-based Study of Health in Pomerania (SHIP), 1367 volunteers (563 men, 678 women; median age, 50 years) underwent whole-body magnetic resonance (MR) imaging at 1.5 T, which included multiecho chemical shift-encoded acquisition of the abdomen. SHIP was approved by the institutional review board, and written informed consent was obtained from all participants. The proton density fat fraction (PDFF) was calculated after correction for T1 bias, T2* bias, multipeak spectral complexity of fat, and noise bias. On the basis of oral glucose tolerance test results, participants were grouped into those with normal glucose tolerance (n = 740), those with prediabetes (n = 431), and those with confirmed type 2 diabetes but without medication (n = 70). PDFF was assessed in the pancreatic head, body, and tail. Multivariable regression analysis was conducted to investigate possible relationships of PDFF with demographic factors, behavioral factors, and laboratory data associated with the metabolic syndrome.Results: In all subjects, the mean unadjusted pancreatic fat content was 4.4% (head, 4.6%; body, 4.9%; tail, 3.9%; being unequally distributed, P < .001). There was no significant difference in pancreatic PDFF among subjects with normal glucose tolerance, prediabetes, and type 2 diabetes (P = .980). Pancreatic PDFF showed a positive association with age and body mass index and a negative association with serum lipase activity (P < .001).Conclusion: The presence of pancreatic fat is not related to prediabetes or diabetes, which suggests that it has little clinical relevance for an individual's glycemic status.