Towards a Clinical Implementation of Measuring the Elastic Modulus of the Aorta From Cardiac Computed Tomography Images
Towards a Clinical Implementation of Measuring the Elastic Modulus of the Aorta From Cardiac Computed Tomography Images
复制标题
从心脏计算机断层扫描图像测量主动脉弹性模量的临床实施
DOI：
10.1109/tbme.2021.3077362
复制
发表时间：
2021
影响因子：
4.6
通讯作者：
Takashi Shirakawa;Toru Kuratani;Masao Yoshitatsu;Kazuo Shimamura;Shinya Fukui;Akira Kurata;Yasushi Koyama;Koichi Toda;Ikuo Fukuda;Yoshiki Sawa
中科院分区：
文献类型：
--
作者：
Amano H;Matsui Y;Hatanaka K;Hosono K;Ito Y.;Takashi Shirakawa;Toru Kuratani;Masao Yoshitatsu;Kazuo Shimamura;Shinya Fukui;Akira Kurata;Yasushi Koyama;Koichi Toda;Ikuo Fukuda;Yoshiki Sawa
目的主动脉壁的弹性随年龄、血管位置和主动脉疾病的存在而变化。非侵入性测量将是了解活体主动脉机械状态的有力工具。本研究的目的是利用计算机断层成像技术来确定主动脉的弹性模数。然后，我们通过对管腔施加四种压力条件对硅橡胶管进行了计算机断层扫描。利用我们的公式从扫描图像中计算出节段的弹性模数。结果4种压力状态下的节段弹性模数分别为0.525[0.524，0.527]，0.524[0.520，0.524]，0.520[0.515，0.523]，0.522[0.516，0.532](单位：兆帕，中位数[25%，75%分位数])。拉伸试验中的相应测量值分别为0.548[0.539，0.566]、0.535[0.528，0.553]、0.526[0.513，0.543]和0.523[0.508，0.530]。这些结果的误差分别为4.2%、2.1%、1.1%和0.2%。结论利用CT图像可以很好地估计硅橡胶管段在生理压力条件下的弹性模数。这些特性可以更好地预测主动脉疾病。这些公式包括医疗环境中常用的临床参数(压力、直径和壁厚)。
ObjectiveThe elasticity of the aortic wall varies depending on age, vessel location, and the presence of aortic diseases. Noninvasive measurement will be a powerful tool to understand the mechanical state of the aorta in a living human body. This study aimed to determine the elastic modulus of the aorta using computed tomography images.MethodsWe constructed our original formulae based on mechanics of materials. Then, we performed computed tomography scans of a silicon rubber tube by applying four pressure conditions to the lumen. The segment elastic modulus was calculated from the scanned images using our formulae. The actual modulus was measured using a tensile loading test for comparison.ResultsThe segment moduli of elasticity from the images were 0.525 [0.524, 0.527], 0.524 [0.520, 0.524], 0.520 [0.515, 0.523], and 0.522 [0.516, 0.532] (unit: MPa, median [25%, 75% quantiles]) for the four pressure conditions, respectively. The corresponding measurements in the tensile test were 0.548 [0.539, 0.566], 0.535 [0.528, 0.553], 0.526 [0.513, 0.543], and 0.523 [0.508, 0.530], respectively. These results indicated errors of 4.2%, 2.1%, 1.1%, and 0.2%, respectively.ConclusionOur formulae provided good estimations of the segment elastic moduli of a silicon rubber tube under physiological pressure conditions using the computed tomography images.SignificanceIn addition to the elasticity, the formulae provide the strain energy as well. These properties can be better predictors of aortic diseases. The formulae consist of clinical parameters commonly used in medical settings (pressure, diameter, and wall thickness).