Nitric oxide and oxygen metabolism
Nitric oxide and oxygen metabolism
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DOI：
10.1042/bst0250901
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发表时间：
1997-08-01
影响因子：
3.9
通讯作者：
Borutaite, V
中科院分区：
文献类型：
--
作者：
Brown, GC;McBride, AG;Borutaite, V
Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1, 2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that:(a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, nerve terminals and cells;(b) NO causes glutamate release from brain nerve terminals probably by inhibiting cytochrome oxidase;(c) cultured astrocytes expressing the inducible form of NO synthase (iNOS) reversibly inhibit their own respiration via the inhibition of cytochrome oxidase;(d) mitochondria cause NO breakdown;(e) NO reversibly inhibits catalase;(f) NO and H202 react with superoxide dismutase (SOD) to produce peroxynitrite;(g) the reaction between NO and oxyhaemoglobin is much slower in intact blood than in blood after the membranes have been lysed.
