Calcium signaling in sperm: help from prostasomes.
Calcium signaling in sperm: help from prostasomes.
复制标题
精子中的钙信号传导：前列腺体的帮助。
DOI：
10.1126/scisignal.2002102
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发表时间：
2011
影响因子：
7.3
通讯作者：
Ren,Dejian
中科院分区：
文献类型：
--
作者：
Ren,Dejian
哺乳动物精子细胞具有复杂的Ca2+信号机制，这是精子成功受精的基础。然而，与大多数其他细胞不同，成熟精子通常没有合成新蛋白质的奢侈。新的证据表明，人类精子有一种非常聪明的方法来解决对Ca2+信号工具的关键需求与蛋白质翻译沉默之间的冲突。就在遇到女性生殖道之前，精子从男性生殖道本身获得了一些Ca2+信号的关键分子：前列腺分泌的前列腺小体。
Mammalian sperm cells are equipped with sophisticated Ca2+signaling mechanisms that are fundamental to sperm’s success in fertilization. Unlike most other cells, however, mature sperm generally do not have the luxury of synthesizing new proteins. New evidence indicates that human sperm have a very clever way to solve the conflict between the critical demand for Ca2+signaling tools and the silence of protein translation. Just before encountering the female reproductive tract, sperm acquire some of the key molecules for Ca2+signaling from the male reproductive tract itself: prostasomes secreted by the prostate gland.