The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs
The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs
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DOI：
10.1016/j.jpsychores.2012.09.002
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发表时间：
2013-01-01
影响因子：
4.7
通讯作者：
Clauw, Daniel J.
中科院分区：
文献类型：
--
作者：
Warren, John W.;Langenberg, Patricia;Clauw, Daniel J.
目的：本研究的目的是检验功能性躯体综合征 (FSS) 的数量可预测新的、额外的 FSS 的假设。方法：在最近一项关于间质性膀胱炎/膀胱疼痛综合征 (IC/PBS) 的病例对照研究中，我们使用基于症状的共识定义来识别这些 FSS：纤维肌痛 (FM)、慢性疲劳综合征 (CFS)、肠易激综合征 (IBS)、慢性盆腔疼痛、偏头痛、干燥综合症和恐慌症。那些在发病年份之前出现的称为先行 FSS；那些在发病年份发病的被称为事件 FSS。在。两组各有 312 例 IC/PBS 病例和 313 例对照，比较具有 0、1、2 或 >= 3 个先前 FSS 的患者的 FSS 发生率。使用逻辑回归分析来评估混杂因素，其中包括单个先前的 FSS、已发表的这些 FSS 的相关性以及人口统计学变量。 结果：新 FSS 的发生率随着先前 FSS 的数量而增加，单独研究的事件 FM、CFS 和 IBS 的发生率也是如此。这些发现并未与其他变量混淆。对于新的、不同的事件 FSS，多个先前 FSS 的存在通常具有最高的比值比。结论：这项研究表明，先前 FSS 的数量是其他 FSS 的最强风险因素之一，尤其是事件 FM、CFS 和 IBS。这表明 FSS 通过多综合征表型联系在一起。如果每个 FSS 是异质的，为了寻找所有 FSS 共有的发病机制，应寻找具有多个 FSS 的个体；为了寻找特定 FSS 特有的发病机制，应对仅具有该 FSS 的成熟人群进行研究。 (C) 2012 Elsevier Inc. 保留所有权利..
Objective: The objective of this study is to test the hypothesis that the number of functional somatic syndromes (FSSs) predicts new, additional FSSs.Methods: In a recent case-control study of interstitial cystitis/painful bladder syndrome (IC/PBS), we used symptom-based consensus definitions to identify these FSSs: fibromyalgia (FM), chronic fatigue syndrome (CFS), irritable bowel syndrome (IBS), chronic pelvic pain, migraine, sicca syndrome and panic disorder. Those, present before the incidence year were called antecedent FSSs; those with onset during the incidence year were called incident FSSs. In. each of two groups, 312 IC/PBS cases and 313 controls, rates of incident FSSs were compared among those with 0, 1, 2, or >= 3 antecedent FSSs. Confounding was assessed using logistic regression analyses that included the individual antecedent FSSs, published correlates of these FSSs, and demographic variables.Results: The incidence of a new FSS increased with the number of antecedent FSSs, as did that of incident FM, CFS and IBS Studied separately. These findings were not confounded by other variables. The Presence of multiple antecedent FSSs generally had the highest odds ratio for new, different, incident FSSs.Conclusions: This study revealed that the number of antecedent FSSs was among the Strongest risk factors for other FSSs, especially incident FM, CFS and IBS. This suggests that the FSSs are linked through a polysyndromic phenotype. If each FSS is heterogeneous, to seek a pathogenesis common to all FSSs, individuals with multiple FSSs should be sought; to seek a pathogenesis unique to a specific FSS, mature persons who have only that FSS should be studied. (C) 2012 Elsevier Inc. All rights reserved..