Endometrial integrins and the establishment of uterine receptivity
Endometrial integrins and the establishment of uterine receptivity
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DOI：
10.1093/humrep/13.suppl_3.247
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发表时间：
1998-06-01
影响因子：
6.1
通讯作者：
Lessey, BA
中科院分区：
文献类型：
--
作者：
Lessey, BA
我们对母体和胚胎上皮细胞之间最初相互作用导致成功着床的因素的理解仍然不完整。特定子宫内膜肽的时空表达可能有助于子宫容受性时期的建立，从而使子宫内膜变得适合植入的胚泡。未能建立接受性可能是女性不孕症的重要原因，特别是影响黄体功能不全、子宫内膜异位症、输卵管积水、复发性流产和不明原因不孕症的女性。整合素是细胞粘附分子的一个家族，现已被广泛接受为子宫容受性的标志物。它们在月经周期中的表达模式表明，整合素也可能提供一种研究调节子宫容受性建立的因素的方法。玻连蛋白受体是一种α（v）β（3）整联蛋白，在假定的着床窗口打开期间出现。其表达似乎与上皮雌激素和孕激素受体（PR）的下调有关。我们推测，子宫内膜上皮PR的选择性丧失对子宫容受性的建立至关重要，并允许通过特定的生长因子由底层基质产生旁分泌影响。在某些不孕状态中发现的整合素正常模式的破坏也可能反映了旁分泌环境的变化，可能是由于与子宫内膜异位症或输卵管疾病相关的炎性细胞因子的影响。了解是什么调节和失调子宫内膜整合素可能会导致更好的治疗和诊断不孕症患者的策略，以及新的避孕方法。
Our understanding of the factors responsible for the initial interaction between maternal and embryonic epithelium leading to successful implantation remains incomplete. Temporal and spatial expression of specific endometrial peptides may contribute to the establishment of a period of uterine receptivity, whereby the endometrium becomes hospitable to the implanting blastocyst. The failure to establish receptivity may account for a significant number of cases of infertility in the female, especially affecting women with luteal phase deficiency, endometriosis, hydrosalpinges, recurrent pregnancy loss and unexplained infertility. Integrins are a family of cell adhesion molecules that have now been largely accepted as markers of uterine receptivity. Their pattern of expression during the menstrual cycle suggests that integrins may also provide a means to study the factors that regulate the establishment of uterine receptivity in general. The vitronectin receptor is an alpha(v)beta(3) integrin that appears during the opening of the putative window of implantation. Its expression appears to be associated with the downregulation of epithelial oestrogen and progesterone receptors (PR). We postulate that the selective loss of PR on endometrial epithelium is critical to the establishment of uterine receptivity and allows the emergence of paracrine influence by underlying stroma through specific growth factors. Disruption of the normal pattern of integrins found in certain infertility states may also reflect a shift in the paracrine milieu, possibly due to the influence of inflammatory cytokines associated with endometriosis or tubal disease. Understanding what regulates and dysregulates endometrial integrins may lead to better treatment and diagnostic strategies for infertility patients as well as novel approaches to contraception.