Differences in calcium metabolism between black and white men and women
Differences in calcium metabolism between black and white men and women
复制标题
DOI：
10.1159/000057442
复制
发表时间：
1999-05-01
期刊：
影响因子：
--
通讯作者：
Tolan, K
中科院分区：
文献类型：
--
作者：
Bikle, DD;Ettinger, B;Tolan, K
为了确定环境因素是否会影响钙代谢的种族差异，作者评估了三个因素（季节、阳光照射时间和饮食）对25-36岁非卧床人群促钙激素、肾钙排泄和骨转换标志物的影响，其中包括109名黑人男性、114名白色男性、95名黑人女性和84名白色女性。与白色受试者相比，两种性别的黑人受试者的血清25-羟维生素D（25-OHD）水平较低，血清1，25-二羟维生素D [1，25（OH）（2）D]水平较高。在所有组中，25-OHD的平均冬季水平比夏季水平低19%至29%。黑人男性尿钙排泄量比白色男性低26%，黑人女性尿钙排泄量比白色女性低36%。黑人女性的甲状旁腺激素水平比白色女性高29%，但男性甲状旁腺激素水平没有统计学显著的种族差异。骨转换标志物（血清骨钙素，骨特异性碱性磷酸酶，尿吡啶啉交联排泄）没有显示一致的种族差异。钙排泄的种族和性别差异与生活方式或促钙激素水平的差异无显著相关性。环境因素，如饮食和阳光照射似乎不影响促钙激素或肾钙排泄水平的种族差异。
To determine whether environmental factors influence racial differences in calcium metabolism, the authors evaluated the influence of three factors (season, length of sunlight exposure, and diet) on calciotropic hormones, renal calcium excretion, and markers of bone turnover in an ambulatory population aged 25-36 years, Included were 109 black men, 114 white men, 95 black women, and 84 white women. Compared with white subjects, black subjects of both genders showed lower levels of serum 25-hydroxyvitamin D (25-OHD) and higher levels of serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. The mean winter levels of 25-OHD were 19 to 29% lower than the summer levels in all groups. The urinary calcium excretion was 26% lower in black men than in white men and was 36% lower in black women than in white women. The parathyroid hormone levels were 29% higher in black women than in white women, but no statistically significant racial differences in parathyroid hormone levels were seen in men. Bone turnover markers (serum osteocalcin, bone-specific alkaline phosphatase, urinary pyridinoline cross-link excretion) did not show consistent racial differences. Racial and gender differences in calcium excretion did not significantly correlate with differences in lifestyle or with levels of the calciotropic hormones. Environmental factors such as diet and sunlight exposure do not appear to influence racial differences in the levels of the calciotropic hormones or renal calcium excretion.