Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles
Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles
复制标题
DOI：
10.1016/s0300-483x(97)00096-6
复制
发表时间：
1997-10-19
期刊：
影响因子：
4.5
通讯作者：
Sagai, M
中科院分区：
文献类型：
--
作者：
Ichinose, T;Takano, H;Sagai, M
为了阐明柴油机尾气颗粒物（DEP）调节的过敏性气道炎症的表现与免疫球蛋白产生之间的关系，在用卵清蛋白（OA）免疫后的5种小鼠中研究了以嗜酸性粒细胞浸润、杯状细胞增殖和抗原特异性免疫球蛋白（IG）产生为特征的气道炎症。以3周的间隔，用OA（1 μ g）或OA（1 μ g）+ DEP（50 μ g）对小鼠进行四次气管内注射。单独用OA处理的小鼠品系的血浆中抗原特异性IgG 1产生的顺序为CBA/2N
To clarify the relationship between the manifestations of allergic airway inflammation modulated by diesel exhaust particles (DEP) and immunoglobulin production in response to an antigen, airway inflammation characterized by the infiltration of eosinophils, goblet cell proliferation, and antigen-specific immunoglobulin (Ig) production was investigated in five strains of mice after immunization with ovalbumin (OA). Mice were injected intratracheally with OA (1 mu g) or OA (1 mu g) + DEP (50 mu g) four times at 3-week intervals. The order of antigen-specific IgG1 production in plasma of mouse strains treated with OA alone was CBA/2N