Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis
Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis
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DOI：
10.1200/jco.2005.01.7145
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发表时间：
2005-12-01
影响因子：
45.3
通讯作者：
Carrie, C
中科院分区：
文献类型：
--
作者：
Arpin, D;Perol, D;Carrie, C
目的探讨白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）在慢性乙型肝炎（HCC）中的变化（TNF α），和白细胞介素-10（IL-10）的变化，并将这些变化与放射性肺炎的发生相关联。对I至III期疾病的CRT进行了前瞻性评价。在治疗前、治疗期间每2周和治疗结束时测定循环细胞因子水平。在3D-CRT后6 - 8周前瞻性评价放射性肺炎。在单变量和多变量analysis.Results 40例（44%）的临床，剂量测定和生物（细胞因子水平）因素的预测价值进行了评估经历了评分1或更多的放射性肺炎。基线细胞因子水平与放射性肺炎风险之间没有相关性。在整个人群中，TNFa、IL-6和IL-10的平均水平在放疗期间保持稳定。放射性肺炎患者在3D-CRT期间IL-6水平显著升高（P.047）。在多因素分析中，3D-CRT前2周内IL-6和IL-10水平的协变被证明是放射性肺炎的独立预测因素（P = 0.011）。结论3D-CRT期间循环IL-6和IL-10水平的早期变化与放射性肺炎的风险显著相关。3D-CRT期间循环IL-6和IL-10水平的变化可作为该并发症的独立预测因素。
Purpose To investigate variations of circulating serum levels of interleukin (IL-6), tumor necrosis factor alpha (TNF alpha), and interleukin-10 (IL-10) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer and correlate these variations with the occurrence of radiation pneumonitis.Patients and Methods Ninety-six patients receiving 3D-CRT for stage I to III disease were evaluated prospectively. Circulating cytokine levels were determined before, every 2 weeks during, and at the end of treatment. Radiation pneumonitis was evaluated prospectively between 6 and 8 weeks after 3D-CRT. The predictive value of clinical, dosimetric, and biologic (cytokine levels) factors was evaluated both in univariate and multivariate analyses.Results Forty patients (44%) experienced score 1 or more radiation pneumonitis. No association was found between baseline cytokine levels and the risk of radiation pneumonitis. In the whole population, mean levels of TNFa, IL-6, and IL-10 remained stable during radiotherapy. IL-6 levels were significantly higher (P.047) during 3D-CRT in patients with radiation pneumonitis. In the multivariate analysis, covariations of IL-6 and IL-10 levels during the first 2 weeks of 3D-CRT were evidenced as independently predictive of radiation pneumonitis in this series (P = .011).Conclusion Early variations of circulating IL-6 and IL-10 levels during 3D-CRT are significantly associated with the risk of radiation pneumonitis. Variations of circulating IL-6 and IL-10 levels during 3D-CRT may serve as independent predictive factors for this complication.