The Alkaloids of Cephalotaxus drupacea and Cephalotaxus fortunei
The Alkaloids of Cephalotaxus drupacea and Cephalotaxus fortunei
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DOI：
10.1021/jo01044a010
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发表时间：
1963-09
影响因子：
3.6
通讯作者：
W. W. Paudler-W.;G. Kerley;J. McKay
中科院分区：
文献类型：
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作者：
W. W. Paudler-W.;G. Kerley;J. McKay
本文报道了云南红豆杉（Ceutaxus drupácea）、2 C.亨利夫角wilsoniaf和C. fortunei 5已被发现，但这些生物碱尚未进行化学研究。本文报道了红豆杉和核果的主要生物碱的分离和部分鉴定。虽然这些植物的植物学分类尚不清楚，但红豆杉通常被列为红豆杉科的一个属和红豆杉科的成员。许多种已被列为Cephalotaxus，6-8，但该属现在被认为只包含四个纯种：C。pedunculata，原产于日本; oliveri，原产于中国; drupácea和C.幸运。9摄氏度。drupácea是一种主要在中国和日本发现的小树，通常被称为牛尾松或日本李紫杉。C.红豆杉，又名中国红豆杉，产于中国北方。C. fortunei和C. Drupácea 1（1）的产率为0.39%和0.百分之三十五通过对浓缩的醇提取物进行常规的酸-碱提取来分别提取粗的甘草酸物质。纸色谱图的比较表明，存在至少四种不同的生物碱在C。Fortunei和C. drupácea。氧化铝柱层析产生一个结晶生物碱从每个物种。这两种生物碱的鉴别是通过比较它们的红外、紫外和核磁共振光谱，以及它们相互混合时熔点的不降低来确定的。这种生物碱被命名为三尖杉碱，在C. fortunei和C. drupácea。
The presence of alkaloids in Cephalotaxus drupácea, 2 C. henryif C. wilsoniaf and C. fortunei5 has been dem-onstrated, but these alkaloids have not been chemi-cally investigated. We now wish to report on the separation and partial identification of the major alkaloid of Cephalotaxus fortunei and drupácea. Although the botanical classification of these plants is not yet clear, Cephalotaxus generally is listed as a genus of the family Taxaceae and a member of the Taxeaef" The Taxaceae belong to the order Coniferae. Many species have been listed for Cephalotaxus, 6-8 but the genus is now considered to containonly four pure ones: C. pedunculata, a native of Japan; C. oliveri, a Native of China; C. drupácea; and C. fortunei. 9 C. drupácea, a small tree which is found predominantly in China and Japan, is commonly known as Cow’s Tail Pine or Japanese plum-yew. C. fortunei, known as the Chinese plum-yew, is found in North China. The powdered leaves andstems of C. fortunei and C. drupácea1 (1 yielded 0.39% and0. 35%., respectively, of crude alkaloidal material by a conventional acid-base extraction of the concentrated alcohol extracts. A comparison of paper chromatograms indicated the presence of at least four different alkaloids in C. fortunei and at least fivedifferent alkaloids in C. drupácea. Alumina-column chromatography yielded one crystalline alkaloid from each species. The identity of these two alkaloids was established by a comparison of their infrared, ultraviolet, and nmr spectra, as well as by the nondepression of their melting points when mixed with each other. This alkaloid which was named cephalotaxine, was present to the extent of 50 and 54%, respectively, in the crude alkaloidal mixtures of C. fortunei and C. drupácea.