Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme.
Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme.
复制标题
胰岛素降解酶对胰岛素降解的自然调节机制。
DOI：
10.1016/0006-291x(90)90539-y
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发表时间：
1990
影响因子：
3.1
通讯作者：
Masato Kasuga
中科院分区：
文献类型：
--
作者：
H. Akiyama;K. Yokono;K. Shii;Wataru Ogawa;H. Taniguchi;S. Baba;Masato Kasuga
Insulin-degrading enzyme (IDE) accounts for most of the insulin degrading activity in extracts of several tissues and plays an important role in the intracellular degradation of insulin. Using newly developed sandwich radioimmunoassay for rat IDE, this enzyme was detectable in all tissues we examined and liver had the highest level of IDE. The ratio of insulin degrading activity to IDE concentration was roughly the same in liver, brain and muscle, however, twice as high in kidney as compared with other tissues. On the contrary, its degrading activity in these tissue extracts, including kidney, was completely lost after immunoprecipitation of IDE. These results suggest that IDE degrades insulin in the initial step of cleavage and that there are some mechanisms to regulate insulin degrading activity by IDE in the tissues.
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从完整大鼠肝脏的内体中分离胰岛素降解产物。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hamel,FG;Posner,BI;Bergeron,JJ;Frank,BH;Duckworth,WC
通讯作者：
Duckworth,WC
[125I]-胰岛素与胞质胰岛素降解酶的体内结合：通过共价交联和单克隆抗体免疫沉淀进行检测。
影响因子：
4.8
作者：
Hari,J;Shii,K;Roth,RA
通讯作者：
Roth,RA
125I-胰岛素与胞质胰岛素降解酶的共价连接。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shii,K;Baba,S;Yokono,K;Roth,RA
通讯作者：
Roth,RA
影响因子：
56.9
作者：
AFFHOLTER, JA;FRIED, VA;ROTH, RA
通讯作者：
ROTH, RA
胰岛素细胞代谢中的肽中间体。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Assoian,RK;Tager,HS
通讯作者：
Tager,HS