Emerging advancements in liver regeneration and organogenesis as tools for liver replacement.
Emerging advancements in liver regeneration and organogenesis as tools for liver replacement.
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DOI：
10.1097/mot.0000000000000365
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发表时间：
2016-12
影响因子：
2.2
通讯作者：
Campbell KM
中科院分区：
文献类型：
--
作者：
Huppert SS;Campbell KM
Although the liver possesses a unique, innate ability to regenerate through mass compensation, transplantation remains the only therapy when damage outpaces regeneration, or liver metabolic capacity is irreversibly impacted. Recent insight from developmental biology has greatly influenced the advancement of alternative options to transplantation in these settings. Factors known to direct liver cell specification, expansion, and differentiation have been used to generate hepatocyte-like cells from stem and somatic cells for cell therapies. Additionally, interactions between hepatic epithelial and non-epithelial cells key to establishing hepatic architecture have been used in tissue engineering approaches to develop self-organizing hepatic organoids and bio-artificial liver devices. Simultaneously, recent clinically applicable advances in human hepatocyte transplantation and promotion of innate hepatic regeneration have been limited. Although mature hepatocytes have the potential to bridge or replace whole organ transplantation, limits in the ability to obtain healthy cells, stabilize in vitro expansion, cryopreservation, and alleviate rejection, still exist. Alternative sources for generating hepatocytes hold promise for cell therapy and tissue engineering. These may allow generation of autologous or universal donor cells that eliminate the need for immunosuppression; however, limits exist regarding hepatocyte maturity and efficacy at liver repopulation, as well as applicability to human chronic liver disease.
