Energy intake and risk of postmenopausal breast cancer: an expanded analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
Energy intake and risk of postmenopausal breast cancer: an expanded analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
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DOI：
10.1158/1055-9965.epi-09-0087
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Ziegler RG
中科院分区：
文献类型：
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作者：
Sue LY;Schairer C;Ma X;Williams C;Chang SC;Miller AB;McCarty CA;Willcox BJ;Ziegler RG
尽管动物实验一直证明乳腺癌和能量摄入之间存在正相关关系，但人类研究的证据仍然没有定论。在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验队列中，29，170名年龄在55-75岁之间的女性在入组时（1993-2001年）成功完成了食物频率问卷（FFQ），随访至2007年;确定了1，319例乳腺癌事件（从FFQ完成到诊断的中位时间为4.4年）。能量摄入量最高四分位数的女性，相对于最低四分位数的女性，乳腺癌风险适度但显著增加[多变量相对风险（RR），1.21; 95%置信区间（95%CI），1.03-1.42; Ptrend = 0.03]。在模型中纳入体重指数和体力活动可略微降低风险（RR，1.18; 95% CI，1.00-1.39; Ptrend = 0.07）。然而，在类似的分析中，使用能量摄入从FFQ管理约5年后进入（27,428名妇女; 806例乳腺癌事件;从FFQ完成诊断的中位时间，2.7年），妇女在最高和最低的四分位数的能量摄入有类似的风险。当第一次FFQ后的随访时间被分为三个四年期时，高能量与低能量摄入的多变量RR从1.21增加到1.37到1.55，随着自饮食评估以来时间的增加。虽然两个FFQ的不同结果可能是由于微妙的问卷差异，但我们的研究结果表明，能量摄入与绝经后乳腺癌之间存在适度的正相关关系，并且随着饮食评估的时间推移而加强。
Although animal experiments have consistently demonstrated a positive relationship between breast cancer and energy intake, evidence from human studies remains inconclusive. In the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort, 29,170 women, aged 55–75 years, who successfully completed a food frequency questionnaire (FFQ) at entry (1993–2001), were followed through 2007; 1,319 incident breast cancers were ascertained (median time from FFQ completion to diagnosis, 4.4 y). Women in the highest quartile of energy intake, relative to the lowest, had modestly, but significantly, increased breast cancer risk [multivariate relative risk (RR), 1.21; 95% confidence interval (95% CI), 1.03–1.42; Ptrend = 0.03]. Including body mass index and physical activity in the model reduced risk slightly (RR, 1.18; 95% CI, 1.00–1.39; Ptrend = 0.07). However, in similar analyses using energy intake from a FFQ administered approximately 5 years after entry (27,428 women; 806 incident breast cancers; median time from FFQ completion to diagnosis, 2.7 y), women in the highest and lowest quartiles of energy intake had similar risk. When follow-up time after the first FFQ was divided into three four-year periods, the multivariate RRs for high versus low energy intake increased from 1.21 to 1.37 to 1.55 with increasing time since dietary assessment. Although the divergent results for the two FFQs could be due to subtle questionnaire differences, our findings suggest a modest positive association between energy intake and postmenopausal breast cancer that strengthens with time since dietary assessment.